Oxytetracycline hyper-production through targeted genome reduction of Streptomyces rimosus - Pšeničnik, Alen; Slemc, Lucija; Avbelj, Martina; Tome, Miha; Šala, Martin; Herron, Paul; Shmatkov, Maksym; Petek, Marko; Baebler, Špela; Mrak, Peter; Hranueli, Daslav; Starčević, Antonio; et al. (mSystems, 2024)
Keywords: Amino acids; Anti-Bacterial Agents - biosynthesis; Antibiotics; Antimicrobial resistance; Applied and Industrial Microbiology; Biosynthesis; Chromosomes; Cryptic gene; Drug development; Gene clusters; Gene deletion; Gene rearrangement; Genes; Genome, Bacterial; Genomes; Genomic analysis; Industrial strains; Metabolism; Metabolites; Microorganisms; Multigene Family - genetics; Mutagenesis; Natural products; Oxytetracycline; Oxytetracycline - biosynthesis; Research Article; Secondary metabolites; Streptomyces - drug effects; Streptomyces - genetics; Streptomyces - metabolism; Streptomyces rimosus; Streptomyces rimosus - genetics; Streptomyces rimosus - metabolism; Transcriptomes; genome reduction; oxytetracycline; antibiotic biosynthesis; cryptic metabolites