Indole Chloropyridinyl Ester-Derived SARS-CoV‑2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X‑ray Structural Studies - Ghosh, Arun K; Raghavaiah, Jakka; Shahabi, Dana; Yadav, Monika; Anson, Brandon J; Lendy, Emma K; Hattori, Shin-ichiro; Higashi-Kuwata, Nobuyo; Mitsuya, Hiroaki; Mesecar, Andrew D (Journal of Medicinal Chemistry, 2021)
Keywords: 1 </ b; 250 nm; 50 </ sub; 73 nm; 7d </ b; 8 μm; Adenosine Monophosphate; Alanine; Animals; antiviral activity; antiviral ec; antiviral efficacy; binding properties; Binding Sites; Biochemistry; Biophysics; Biotechnology; Cancer; Chemical Sciences not elsewhere classified; Chemistry, Medicinal; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19; Crystallography, X-Ray; enzyme inhibition; Humans; immunocytochemistry assays; indole chloropyridinyl ester; Indoles; Infectious Diseases; Information Systems not elsewhere classified; Life Sciences & Biomedicine; like protease inhibitors; Molecular Dynamics Simulation; n; obtain molecular insight; Pharmacology; Pharmacology & Pharmacy; potent class; Protease Inhibitors; Pyridines; ray crystal structures; ray crystallographic studies; SARS-CoV-2; Science & Technology; Structure-Activity Relationship; Vero Cells; veroe6 cells; Virology; DESIGN; REPLICATION; SERIES; PAPAIN-LIKE; BIOLOGICAL EVALUATION; OPTIMIZATION; SARS-CORONAVIRUS; DISCOVERY