Preventive Effects of Taurine on Development of Hepatic Steatosis Induced by a High-Fat/Cholesterol Dietary Habit

• Published in: Journal of agricultural and food chemistry Vol. 59; no. 1; pp. 450 - 457
• Main Authors: Chang, Yuan-Yen, Chou, Chung-Hsi, Chiu, Chih-Hsien, Yang, Kuo-Tai, Lin, Yi-Ling, Weng, Wei-Lien, Chen, Yi-Chen
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 12.01.2011
• Subjects: animal models; Animals; antioxidant activity; Biological and medical sciences; cholesterol; Cholesterol, Dietary - adverse effects; Cholesterol, Dietary - metabolism; Cricetinae; diet-related diseases; dietary fat; Dietary Fats - adverse effects; Dietary Fats - metabolism; Disease Models, Animal; disease prevention; fat intake; fatty liver; Fatty Liver - drug therapy; Fatty Liver - genetics; Fatty Liver - metabolism; Fatty Liver - prevention & control; Food industries; Fundamental and applied biological sciences. Psychology; Gene Expression - drug effects; hamsters; hepatoprotective effect; high fat diet; Humans; Ion Channels - genetics; Ion Channels - metabolism; lipid metabolism; Male; Mesocricetus; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Molecular Nutrition; Non-alcoholic Fatty Liver Disease; PPAR alpha - genetics; PPAR alpha - metabolism; taurine; Taurine - administration & dosage; Uncoupling Protein 2; lipid homeostasis; taurine; hepatic/fecal lipids; Antioxidant capacity/enzyme; serum lipids; hepatic steatosis; Taurine; Enzyme; Lipids; Antioxidant; Cholesterol; Development; Fat; Serum; Feces
• DOI: 10.1021/jf103167u
• ISSN: 0021-8561; 1520-5118

Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become an emergent liver disease in developed and developing nations. This study was to exam the preventive effects of taurine (Tau) on the development of hepatic steatosis via a hamster model. Although hepatic steatosis of hamsters was induced by feeding a high-fat/cholesterol diet, drinking water containing 0.35 and 0.7% Tau improved (p < 0.05) the serum lipid profile. Meanwhile, the smaller (p < 0.05) liver sizes and lower (p < 0.05) hepatic lipids in high-fat/cholesterol dietary hamsters drinking Tau may be partially due to higher (p < 0.05) fecal cholesterol, triacylglycerol, and bile acid outputs. In the regulation of lipid homeostasis, drinking a Tau solution upregulated (p < 0.05) low-density lipoprotein receptor and CYP7A1 gene expressions in high-fat/cholesterol dietary hamsters, which result in increased fecal cholesterol and bile acid outputs. Drinking a Tau solution also upregulated (p < 0.05) peroxisome proliferator-activated receptor-α (PPAR-α) and uncoupling protein 2 (UPC2) gene expressions in high-fat/cholesterol dietary hamsters, thus increasing energy expenditure. Besides, Tau also enhanced (p < 0.05) liver antioxidant capacities (GSH, TEAC, SOD, and CAT) and decreased (p < 0.05) lipid peroxidation (MDA), which alleviated liver damage in the high-fat/cholesterol dietary hamsters. Therefore, Tau shows preventive effects on the development of hepatic steatosis induced by a high-fat/cholesterol dietary habit.