Dysregulation of Regional Endogenous Opioid Function in Borderline Personality Disorder

• Published in: American Journal of Psychiatry Vol. 167; no. 8; pp. 925 - 933
• Main Authors: Prossin, Alan R, Love, Tiffany M, Koeppe, Robert A, Zubieta, Jon-Kar, Silk, Kenneth R
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Association 01.08.2010
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Borderline Personality Disorder - diagnosis; Borderline Personality Disorder - diagnostic imaging; Borderline Personality Disorder - physiopathology; Brain - diagnostic imaging; Brain - physiopathology; Carbon Radioisotopes; Depression - diagnosis; Depression - diagnostic imaging; Depression - physiopathology; Emotions - physiology; Endorphins - physiology; Female; Fentanyl - analogs & derivatives; Humans; Medical sciences; Neurosciences; Neurotransmitter Agents - physiology; Personality disorders; Positron-Emission Tomography; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, Opioid, mu - physiology; Stress; Opiates; Borderline; Opioid peptide; Personality disorder

ObjectiveBorderline personality disorder is characterized by a lack of effective regulation of emotional responses. The authors investigated the role of the endogenous opioid system and μ-opioid receptors in emotion regulation in borderline personality disorder. MethodMu-opioid receptor availability...