Bioavailability of Various Polyphenols from a Diet Containing Moderate Amounts of Berries

• Published in: Journal of agricultural and food chemistry Vol. 58; no. 7; pp. 3927 - 3932
• Main Authors: Koli, Raika, Erlund, Iris, Jula, Antti, Marniemi, Jukka, Mattila, Pirjo, Alfthan, Georg
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Washington, DC American Chemical Society 14.04.2010
• Subjects: 3-hydroxyphenylacetic acid; administration & dosage; Aged; analysis; Aronia; bilberries; bioavailability; Biological and medical sciences; Biological Availability; black currants; blood plasma; caffeic acid; chemical composition; chemistry; diet; Dietary Supplements; Dietary Supplements - analysis; excretion; experimental diets; Feeding. Feeding behavior; Female; Flavonoids; Flavonoids - administration & dosage; Flavonoids - analysis; Flavonoids - pharmacokinetics; Food industries; Fruit; Fruit - chemistry; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; homovanillic acid; human nutrition; Humans; lingonberries; long term experiments; Magnoliopsida; Magnoliopsida - chemistry; Male; Middle Aged; middle-aged adults; nutrition physiology; p-coumaric acid; pharmacokinetics; Phenols; Phenols - administration & dosage; Phenols - analysis; Phenols - pharmacokinetics; phenylacetic acid; phytochemicals; Polyphenols; propionic acid; protocatechuic acid; quercetin; randomized clinical trials; Ribes; Ribes - chemistry; small fruits; urine; Vaccinium myrtillus; Vaccinium myrtillus - chemistry; Vaccinium vitis-idaea; Vaccinium vitis-idaea - chemistry; vanillic acid; Vertebrates: anatomy and physiology, studies on body, several organs or systems; polyphenols; Berries; bioavailability; human; dietary intervention; Human; Polyphenol; Fruit; Diet; Berry; Bioavailability; Feeding
• ISSN: 0021-8561; 1520-5118; 1520-5118
• DOI: 10.1021/jf9024823

Berries are a rich source of various polyphenols. The objective of this study was to investigate the bioavailability of polyphenols from berries. Middle-aged subjects (n = 72) consumed moderate amounts of berry or control products for 8 weeks in a randomized, placebo-controlled dietary intervention trial. Average intake of berries was 160 g/day (bilberries, lingonberries, black currants, and chokeberries). Plasma and urine polyphenols were analyzed by GC-MS and HPLC and berry polyphenols by HPLC. The total intake of polyphenols was 837 mg/day. Plasma quercetin, p-coumaric acid, 3-hydroxyphenylacetic acid, caffeic acid, protocatechuic acid, vanillic acid, homovanillic acid, and 3-(3-hydroxyphenyl)propionic acid increased significantly from the baseline in the berry group compared to the control group (p < 0.05). The urinary excretion of quercetin, p-coumaric acid, and 3-hydroxyphenylacetic acid increased significantly in the berry group compared to the control group (p < 0.05). In conclusion, a number of polyphenols are bioavailable from a diet containing moderate amounts of blue and red berries.