Competitive Inhibition of Renal Tubular Secretion of Gemifloxacin by Probenecid

• Published in: Antimicrobial Agents and Chemotherapy Vol. 53; no. 9; pp. 3902 - 3907
• Main Authors: Landersdorfer, Cornelia B., Kirkpatrick, Carl M. J., Kinzig, Martina, Bulitta, Jürgen B., Holzgrabe, Ulrike, Drusano, George L., Sörgel, Fritz
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.09.2009; American Society for Microbiology (ASM)
• Subjects: Adjuvants, Pharmaceutic; Adjuvants, Pharmaceutic - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Female; Fluoroquinolones; Fluoroquinolones - blood; Fluoroquinolones - pharmacokinetics; Fluoroquinolones - urine; Humans; Kidney Function Tests; Kidney Tubules; Kidney Tubules - drug effects; Kidney Tubules - metabolism; Male; Medical sciences; Metabolic Clearance Rate - drug effects; Naphthyridines; Naphthyridines - blood; Naphthyridines - pharmacokinetics; Naphthyridines - urine; Pharmacology; Pharmacology. Drug treatments; Probenecid; Probenecid - blood; Probenecid - pharmacology; Probenecid - urine; Gemifloxacin; Fluoroquinolone derivatives; Renal tubule; Sulfonamides; Secretion; Antibacterial agent; Competitive inhibition; Uricosuric agent; Quinolone derivatives; Probenecid

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