A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases

• Published in: mBio Vol. 12; no. 5; p. e0254221
• Main Authors: Li, Zhizhen, Wu, Jianping, Zhou, Ji, Yuan, Baoshi, Chen, Jiqiao, Wu, Wanchen, Mo, Lian, Qu, Zhipeng, Zhou, Fei, Dong, Yingying, Huang, Kai, Liu, Zhiwei, Wang, Tao, Symmes, Deebie, Gu, Jingliang, Sho, Eiketsu, Zhang, Jingping, Chen, Ruihuan, Xu, Ying
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 26.10.2021
• Subjects: Host-Microbial Interactions; Research Article; COVID-19; host-directed antiviral; small molecule; vimentin; anti-inflammation

With the Delta variant currently fueling a resurgence of new infections in the fully vaccinated population, developing an effective therapeutic drug is especially critical and urgent in fighting COVID-19. In contrast to the many efforts to repurpose existing drugs or address only one aspect of COVID...