Genistein Targets STING-Driven Antiviral Responses

• Published in: mBio Vol. 13; no. 4; p. e0206422
• Main Authors: Ullah, Tomalika R., Balka, Katherine R., Ambrose, Rebecca L., Pépin, Geneviève, Wilce, Matthew C. J., Wilce, Jacqueline A., Thomas, Belinda J., De Nardo, Dominic, Williams, Bryan R. G., Gantier, Michael P.
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 30.08.2022
• Subjects: cGAMP; gap junction; Genistein; Molecular and Cellular Biology; Observation; STING inhibitor; gap junction; STING inhibitor; cGAMP; Genistein

Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the stimulator of interferon (IFN) genes (STING) in infected and adjacent cells through intercellular transfer by connexins forming gap-junctions, e...