In Vitro Activities of Linezolid against Clinical Isolates of Mycobacterium tuberculosis Complex Isolated in Taiwan over 10 Years
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Published in | Antimicrobial Agents and Chemotherapy Vol. 52; no. 6; pp. 2226 - 2227 |
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Significant increases in the MIC 90 s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 μg/ml) and 2004 (2 μg/ml). The MICs were 4 μg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to have statistically significant degrees of concordance with linezolid. Significant increases in the MIC90s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 μg/ml) and 2004 (2 μg/ml). The MICs were 4 μg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to have statistically significant degrees of concordance with linezolid. Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to have statistically significant degrees of concordance with linezolid.Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to have statistically significant degrees of concordance with linezolid. Significant increases in the MIC sub(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 kg/ml) and 2004 (2 kg/ml). The MICs were 4 kg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to have statistically significant degrees of concordance with linezolid. Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to have statistically significant degrees of concordance with linezolid. |
Author | Bao-Chen Chen Hui-Zin Tu Yao-Shen Chen Yung-Ching Liu Cheng-Len Sy Tsi-Shu Huang |
AuthorAffiliation | Section of Microbiology, Dept. of Pathology and Laboratory Medicine, 1 Section of Infectious Diseases, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 2 Department of Medical Technology, Foo-Yin Institute of Technology, Kaohsiung, Taiwan, 3 School of Medicine, National Yang-Ming University, Taipei, Taiwan, 4 Graduate Institute of Environmental Education, National Kaohsiung Normal University, Kaohsiung, Taiwan 5 |
AuthorAffiliation_xml | – name: Section of Microbiology, Dept. of Pathology and Laboratory Medicine, 1 Section of Infectious Diseases, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 2 Department of Medical Technology, Foo-Yin Institute of Technology, Kaohsiung, Taiwan, 3 School of Medicine, National Yang-Ming University, Taipei, Taiwan, 4 Graduate Institute of Environmental Education, National Kaohsiung Normal University, Kaohsiung, Taiwan 5 |
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Keywords | Human Linezolid Species complex In vitro Biological activity Antibiotic Mycobacterium tuberculosis Mycobacteriales Oxazolidinone derivative Mycobacteriaceae Bacteria Actinomycetes Protein synthesis inhibitor Antibacterial agent Oxazole derivatives Clinical isolate |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author. Mailing address: Section of Infectious Diseases, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Rd., Kaohsiung, Taiwan, Republic of China. Phone: 886 (07)3468169. Fax: 886 (07)3468296. E-mail: ycliu@vghks.gov.tw |
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Reddit... Significant increases in the MIC 90 s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to... Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to... Significant increases in the MIC90s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to... Significant increases in the MIC sub(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001... |
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SubjectTerms | Acetamides Acetamides - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents Antitubercular Agents - pharmacology Biological and medical sciences Drug Resistance, Bacterial Fluoroquinolones - pharmacology Humans Linezolid Medical sciences Microbial Sensitivity Tests - standards Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Oxazolidinones Oxazolidinones - pharmacology Pharmacology. Drug treatments Susceptibility Taiwan - epidemiology Tuberculosis Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis, Multidrug-Resistant Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - microbiology |
Title | In Vitro Activities of Linezolid against Clinical Isolates of Mycobacterium tuberculosis Complex Isolated in Taiwan over 10 Years |
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