Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence

• Published in: The American journal of psychiatry Vol. 174; no. 12; pp. 1185 - 1194
• Main Authors: Lutz, Pierre-Eric, Tanti, Arnaud, Gasecka, Alicja, Barnett-Burns, Sarah, Kim, John J, Zhou, Yi, Chen, Gang G, Wakid, Marina, Shaw, Meghan, Almeida, Daniel, Chay, Marc-Aurele, Yang, Jennie, Larivière, Vanessa, M’Boutchou, Marie-Noël, van Kempen, Léon C, Yerko, Volodymyr, Prud’homme, Josée, Davoli, Maria Antonietta, Vaillancourt, Kathryn, Théroux, Jean-François, Bramoullé, Alexandre, Zhang, Tie-Yuan, Meaney, Michael J, Ernst, Carl, Côté, Daniel, Mechawar, Naguib, Turecki, Gustavo
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.12.2017; American Psychiatric Publishing
• Subjects: Adult Survivors of Child Abuse; Animals; Axons - pathology; Brain; Case-Control Studies; Cell Count; Child abuse & neglect; Children; Deoxyribonucleic acid; DNA; DNA Methylation; Epigenesis, Genetic; Epigenetics; Gene Expression; Genetics; Genomics; Gyrus Cinguli - metabolism; History; Humans; Life; Life Sciences; Mental health; Morphology; Myelin Sheath - metabolism; Myelin Sheath - ultrastructure; Neurons - metabolism; Oligodendroglia - metabolism; Rats; Research subjects; Suicide; Technology; Transcription factors; Transcription, Genetic; Molecular Biology; Mood Disorders-Unipolar; Suicide; Neuropathology

Objective:Child abuse has devastating and long-lasting consequences, considerably increasing the lifetime risk of negative mental health outcomes such as depression and suicide. Yet the neurobiological processes underlying this heightened vulnerability remain poorly understood. The authors investiga...