Isolation, Structural Elucidation, and Liquid Chromatography–Mass Spectrometry Analysis of Steroidal Glycosides from Polygonatum odoratum

The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1–8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectrosco...

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Published inJournal of Agricultural and Food Chemistry Vol. 66; no. 2; pp. 521 - 531
Main Authors Liu, Qingbo, Li, Wei, Nagata, Kazuya, Fu, Hongwei, Okada, Shunpei, Tanabe, Ikumi, Kobori, Yumi, Higai, Koji, Norie, Wada, Sasaki, Tatsunori, Asada, Yoshihisa, Zhao, Huanxin, Bai, Hong, Koike, Kazuo
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 17.01.2018
American Chemical Society (ACS)
Amer Chemical Soc
Subjects
Agriculture
Agriculture, Multidisciplinary
autumn
biosynthesis
Cell Proliferation
Cell Survival
chemical constituents of plants
chemical reactions
Chemistry
Chemistry, Applied
chemotaxonomy
Chromatography, Liquid
Food Science & Technology
functional foods
Geographical Locations
Glycosides
Hep G2 Cells
hepatoma
human cell lines
Humans
inhibitory concentration 50
Life Sciences & Biomedicine
liquid chromatography
Mass Spectrometry
Molecular Structure
neoplasm cells
Oriental traditional medicine
Physical Sciences
Plant Extracts
Polygonatum
Polygonatum odoratum
quality control
Rhizome
rhizomes
Science & Technology
spectral analysis
spring
Steroids
structural elucidation
antiproliferation activity
Polygonatum odoratum
LC−MS analysis
steroidal glycosides
APOPTOSIS
LC-MS analysis
SAPONINS
antiptoliferation activity
RHIZOMES
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Abstract The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1–8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC50 of 3.2 μM). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P. odoratum samples and have potential to serve as chemotaxonomic and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1–7.
AbstractList The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1-8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC of 3.2 μM). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P. odoratum samples and have potential to serve as chemotaxonomic and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1-7.
The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1–8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC₅₀ of 3.2 μM). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P. odoratum samples and have potential to serve as chemotaxonomic and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1–7.
The rhizomeg of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in, the isolation of eight steroidal glycosides (1-8), including two new compounds, polygonatumosides F(1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC50 of 3.2 mu M). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes Collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P.,odoratum samples and have potential to serve as chemotaxonomie and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1-7.
The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1–8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC50 of 3.2 μM). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P. odoratum samples and have potential to serve as chemotaxonomic and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1–7.
The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1-8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC50 of 3.2 μM). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P. odoratum samples and have potential to serve as chemotaxonomic and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1-7.The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1-8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC50 of 3.2 μM). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P. odoratum samples and have potential to serve as chemotaxonomic and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1-7.
Author Kobori, Yumi
Bai, Hong
Asada, Yoshihisa
Zhao, Huanxin
Li, Wei
Okada, Shunpei
Koike, Kazuo
Tanabe, Ikumi
Liu, Qingbo
Nagata, Kazuya
Fu, Hongwei
Higai, Koji
Norie, Wada
Sasaki, Tatsunori
AuthorAffiliation Faculty of Pharmaceutical Sciences
Industrial Technology Research Institute of Zhejiang University
Toho University
Institute of Materia Medica
College of Life Science and Technology
Huazhong University of Science and Technology
Zhejiang University Technology Transfer Center
Shandong Academy of Medical Sciences
AuthorAffiliation_xml – name: Industrial Technology Research Institute of Zhejiang University
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Cites_doi 10.1080/14786419.2012.701212
10.1271/bbb.66.2036
10.1016/j.bmcl.2013.04.027
10.1248/cpb.32.1365
10.1021/np50068a010
10.1016/j.jchromb.2015.01.030
10.1016/j.foodchem.2008.03.015
10.1016/j.foodchem.2006.11.045
10.1016/j.steroids.2015.12.013
10.1002/mrc.1474
10.1016/j.steroids.2013.11.013
10.1016/j.phytochem.2004.07.013
10.1021/np980346b
10.1371/journal.pone.0101526
10.3892/etm.2016.3630
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Issue 2
Keywords structural elucidation
antiproliferation activity
Polygonatum odoratum
LC−MS analysis
steroidal glycosides
APOPTOSIS
LC-MS analysis
SAPONINS
antiptoliferation activity
RHIZOMES
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References ref9/cit9
ref17/cit17
ref6/cit6
ref3/cit3
ref18/cit18
ref19/cit19
ref12/cit12
ref15/cit15
ref16/cit16
Bogacheva N. G. (ref11/cit11) 1977; 11
ref13/cit13
ref14/cit14
ref8/cit8
ref5/cit5
ref2/cit2
ref4/cit4
ref1/cit1
Meng Z. Y. (ref10/cit10) 1999; 9
ref20/cit20
ref7/cit7
Liu, ZH (WOS:000371191000011) 2016; 106
SUGIYAMA, M (WOS:A1984SR91800013) 1984; 32
Li, CY (WOS:000341253400084) 2014; 9
Rafi, MM (WOS:000246630500045) 2007; 104
Yang, L. S. (000423012900015.17) 1991
SON, KH (WOS:A1990DD95400010) 1990; 53
Yu, GF (WOS:000257024700028) 2008; 110
Zhou, XL (WOS:000350925800019) 2015; 985
Bai, H (WOS:000331671100002) 2014; 80
Guo, HJ (WOS:000318976100001) 2013; 23
Agrawal, PK (WOS:000224875300015) 2004; 42
Braca, A (WOS:000225151400012) 2004; 65
BOGACHEVA, NG (WOS:A1977DP62000016) 1977; 11
Wang, DM (WOS:000320582300010) 2013; 27
Zhonghuabencao Editorial Board (000423012900015.1) 1999; 8
Meng, Z. Y. (000423012900015.10) 1999; 9
Choi, SB (WOS:000179001800004) 2002; 66
Mimaki, Y (WOS:000078186300047) 1999; 62
Yu, C. (000423012900015.18) 1993; 1
Tai, Y (WOS:000385578200115) 2016; 12
References_xml – ident: ref3/cit3
  doi: 10.1080/14786419.2012.701212
– ident: ref6/cit6
  doi: 10.1271/bbb.66.2036
– ident: ref8/cit8
  doi: 10.1016/j.bmcl.2013.04.027
– ident: ref13/cit13
  doi: 10.1248/cpb.32.1365
– ident: ref2/cit2
– ident: ref12/cit12
  doi: 10.1021/np50068a010
– ident: ref20/cit20
– ident: ref5/cit5
  doi: 10.1016/j.jchromb.2015.01.030
– ident: ref17/cit17
  doi: 10.1016/j.foodchem.2008.03.015
– ident: ref7/cit7
  doi: 10.1016/j.foodchem.2006.11.045
– ident: ref18/cit18
  doi: 10.1016/j.steroids.2015.12.013
– ident: ref16/cit16
  doi: 10.1002/mrc.1474
– ident: ref9/cit9
  doi: 10.1016/j.steroids.2013.11.013
– volume: 9
  start-page: 294
  year: 1999
  ident: ref10/cit10
  publication-title: Zhongguo Yaowu Huaxue Zazhi
– ident: ref15/cit15
  doi: 10.1016/j.phytochem.2004.07.013
– ident: ref14/cit14
  doi: 10.1021/np980346b
– ident: ref19/cit19
  doi: 10.1371/journal.pone.0101526
– volume: 11
  start-page: 65
  year: 1977
  ident: ref11/cit11
  publication-title: Khim.-Farm. Zh.
– ident: ref4/cit4
  doi: 10.3892/etm.2016.3630
– ident: ref1/cit1
– volume: 27
  start-page: 1111
  year: 2013
  ident: WOS:000320582300010
  article-title: Antioxidant activities of different extracts and homoisoflavanones isolated from the Polygonatum odoratum
  publication-title: NATURAL PRODUCT RESEARCH
  doi: 10.1080/14786419.2012.701212
– volume: 80
  start-page: 7
  year: 2014
  ident: WOS:000331671100002
  article-title: Isolation and structural elucidation of novel cholestane glycosides and spirostane saponins from Polygonatum odoratum
  publication-title: STEROIDS
  doi: 10.1016/j.steroids.2013.11.013
– volume: 65
  start-page: 2921
  year: 2004
  ident: WOS:000225151400012
  article-title: Furostanol saponins and quercetin glycosides from the leaves of Helleborus viridis L.
  publication-title: PHYTOCHEMISTRY
  doi: 10.1016/j.phytochem.2004.07.013
– volume: 12
  start-page: 2681
  year: 2016
  ident: WOS:000385578200115
  article-title: Effect of Polygonatum odoratum extract on human breast cancer MDA-MB-231 cell proliferation and apoptosis
  publication-title: EXPERIMENTAL AND THERAPEUTIC MEDICINE
  doi: 10.3892/etm.2016.3630
– volume: 62
  start-page: 194
  year: 1999
  ident: WOS:000078186300047
  article-title: Steroidal glycosides from the bulbs of Allium jesdianum
  publication-title: JOURNAL OF NATURAL PRODUCTS
– volume: 66
  start-page: 2036
  year: 2002
  ident: WOS:000179001800004
  article-title: A steroidal glycoside from Polygonatum odoratum (Mill.) Druce. improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats
  publication-title: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
– volume: 23
  start-page: 3137
  year: 2013
  ident: WOS:000318976100001
  article-title: A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2013.04.027
– volume: 42
  start-page: 990
  year: 2004
  ident: WOS:000224875300015
  article-title: Dependence of H-1 NMR chemical shifts of geminal protons of glycosyloxy methylene (H-2-26) on the orientation of the 27-methyl group of furostane-type steroidal saponins
  publication-title: MAGNETIC RESONANCE IN CHEMISTRY
  doi: 10.1002/mrc.1474
– volume: 110
  start-page: 991
  year: 2008
  ident: WOS:000257024700028
  article-title: Non-nutritive functional agents in rattan-shoots, a food consumed by native people in the Philippines
  publication-title: FOOD CHEMISTRY
  doi: 10.1016/j.foodchem.2008.03.015
– volume: 9
  start-page: ARTN e101526
  year: 2014
  ident: WOS:000341253400084
  article-title: Molecular Switch Role of Akt in Polygonatum odoratum Lectin-Induced Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer A549 Cells
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0101526
– volume: 53
  start-page: 333
  year: 1990
  ident: WOS:A1990DD95400010
  article-title: STEROIDAL SAPONINS FROM THE RHIZOMES OF POLYGONATUM-SIBIRICUM
  publication-title: JOURNAL OF NATURAL PRODUCTS
– volume: 1
  start-page: 1331
  year: 1993
  ident: 000423012900015.18
  publication-title: A Dictionary of the Traditional Chinese Medicine
– volume: 985
  start-page: 149
  year: 2015
  ident: WOS:000350925800019
  article-title: Separation and purification of alpha-glucosidase inhibitors from Polygonatum odoratum by stepwise high-speed counter-current chromatography combined with Sephadex LH-20 chromatography target-guided by ultrafiltration-HPLC screening
  publication-title: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
  doi: 10.1016/j.jchromb.2015.01.030
– volume: 106
  start-page: 86
  year: 2016
  ident: WOS:000371191000011
  article-title: Bioactive spirostane glycosides from Tacca plantaginea
  publication-title: STEROIDS
  doi: 10.1016/j.steroids.2015.12.013
– volume: 104
  start-page: 332
  year: 2007
  ident: WOS:000246630500045
  article-title: Identification of a structure specific Bcl-2 phosphorylating homoisoflavone molecule from Vietnamese coriander (Polygonatum odoratum) that induces apoptosis and G2/M cell cycle arrest in breast cancer cell lines
  publication-title: FOOD CHEMISTRY
  doi: 10.1016/j.foodchem.2006.11.045
– volume: 11
  start-page: 65
  year: 1977
  ident: WOS:A1977DP62000016
  article-title: STRUCTURE OF JAMOGENIN TETRAOZIDE FROM TRINGONELLA FOENUM-GRAECUM SEEDS
  publication-title: KHIMIKO-FARMATSEVTICHESKII ZHURNAL
– volume: 8
  start-page: 7198
  year: 1999
  ident: 000423012900015.1
  publication-title: Zhonghuabencao
– start-page: 62
  year: 1991
  ident: 000423012900015.17
  publication-title: Dietary Treatment of Chinese Medicine
– volume: 32
  start-page: 1365
  year: 1984
  ident: WOS:A1984SR91800013
  article-title: 5 STEROIDAL COMPONENTS FROM THE RHIZOMES OF POLYGONATUM-ODORATUM VAR PLURIFLORUM
  publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN
– volume: 9
  start-page: 294
  year: 1999
  ident: 000423012900015.10
  article-title: New saponins from Anemarrhena asphodeloides Bge
  publication-title: Zhongguo Yaowu Huaxue Zazhi
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Snippet The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of...
The rhizomeg of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in, the isolation of...
Source Web of Science
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StartPage 521
SubjectTerms Agriculture
Agriculture, Multidisciplinary
autumn
biosynthesis
Cell Proliferation
Cell Survival
chemical constituents of plants
chemical reactions
Chemistry
Chemistry, Applied
chemotaxonomy
Chromatography, Liquid
Food Science & Technology
functional foods
Geographical Locations
Glycosides
Hep G2 Cells
hepatoma
human cell lines
Humans
inhibitory concentration 50
Life Sciences & Biomedicine
liquid chromatography
Mass Spectrometry
Molecular Structure
neoplasm cells
Oriental traditional medicine
Physical Sciences
Plant Extracts
Polygonatum
Polygonatum odoratum
quality control
Rhizome
rhizomes
Science & Technology
spectral analysis
spring
Steroids
Title Isolation, Structural Elucidation, and Liquid Chromatography–Mass Spectrometry Analysis of Steroidal Glycosides from Polygonatum odoratum
URI http://dx.doi.org/10.1021/acs.jafc.7b04488
https://cir.nii.ac.jp/crid/1870302167673430528
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https://www.ncbi.nlm.nih.gov/pubmed/29262679
https://www.proquest.com/docview/1979498003
https://www.proquest.com/docview/2116911563
Volume 66
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