Phenolic Compounds Rutin and o-Coumaric Acid Ameliorate Obesity Induced by High-Fat Diet in Rats

• Published in: Journal of agricultural and food chemistry Vol. 57; no. 2; pp. 425 - 431
• Main Authors: Hsu, Chin-Lin, Wu, Chi-Hao, Huang, Shih-Li, Yen, Gow-Chin
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 28.01.2009
• Subjects: adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Animals; antiobesity activity; Bioactive Constituents; Biological and medical sciences; blood chemistry; blood lipids; body fat; Body Weight; Body Weight - drug effects; coumaric acids; Coumaric Acids - metabolism; Coumaric Acids - pharmacology; Dietary Fats; Dietary Fats - metabolism; drug effects; drug therapy; epididymal fat pads; fat intake; Feeding. Feeding behavior; Female; Food industries; food intake; Fundamental and applied biological sciences. Psychology; high fat diet; Humans; insulin; leptin; liver; Liver - drug effects; Liver - metabolism; metabolism; o-coumaric acid; obesity; Obesity - drug therapy; Obesity - metabolism; oxidative stress; Oxidative Stress - drug effects; peritoneal fat pads; pharmacology; Rats; Rats, Wistar; rutin; Rutin - metabolism; Rutin - pharmacology; tallow; triacylglycerols; Vertebrates: anatomy and physiology, studies on body, several organs or systems; weight; hepatosteatosis; Rutin; dyslipidemia; oxidative stress; o-coumaric acid; Obesity; Oxidative stress; Rat; Rodentia; Nutrition disorder; Feeding; Vertebrata; Mammalia; Acids; Diet; Fat; Phenols; Nutritional status
• DOI: 10.1021/jf802715t
• ISSN: 0021-8561; 1520-5118

Dietary fat is one of the most important environmental factors associated with the incidence of cardiovascular diseases. In this study, the antiobesity effects of rutin (R) and o-coumaric acid (oCA) were investigated. Wistar rats were divided into normal and obese groups, and obese rats were prefed a high-fat diet (HFD) containing 40% beef tallow for 4 weeks. Then, R and oCA were given as a supplement to obese rats at doses of 50 and 100 mg/kg, respectively, for a period of 8 weeks. The results showed that body, liver organ, and adipose tissue weights of peritoneal and epididymal fat pads in the HFD+ R and HFD+oCA groups were significantly decreased as compared to those in the HFD group. Serum lipid profiles, insulin, and leptin were significantly decreased in the HFD+ R (high dose, HD) and HFD+oCA (HD) groups as compared to those in the HFD group. Hepatic triacylglycerol and cholesterol levels were significantly decreased in the HFD+ R (HD) and HFD+oCA (HD) groups as compared to those in the HFD group. Moreover, the consumption of R and oCA reduced oxidative stress and glutathione disulfide (GSSG) content, and enhanced the levels of glutathione (GSH), GSH peroxidase (GPx), GSH reductase (GRd), and GSH S-transferase (GST) in the hepatic tissue of rats with HFD-induced obesity. These results demonstrate that intake of R and oCA can be beneficial for the suppression of high-fat-diet-induced dyslipidemia, hepatosteatosis, and oxidative stress in rats.