Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients

• Published in: JAMA internal medicine Vol. 181; no. 8; p. 1100
• Main Authors: Van Driest, Sara L, Abul-Husn, Noura S, Glessner, Joseph T, Bastarache, Lisa, Nirenberg, Sharon, Schildcrout, Jonathan S, Eswarappa, Meghana S, Belbin, Gillian M, Shaffer, Christian M, Mentch, Frank, Connolly, John, Shi, Mingjian, Stein, C Michael, Roden, Dan M, Hakonarson, Hakon, Cox, Nancy J, Borinstein, Scott C, Mosley, Jonathan D
• Format: Journal Article
• Language: English
• Published: United States 01.08.2021
• Subjects: Adult; African Americans - genetics; Biopsy - methods; Biopsy - statistics & numerical data; Bone Marrow Examination - methods; Bone Marrow Examination - statistics & numerical data; Duffy Blood-Group System - genetics; Female; Gene Expression Profiling - statistics & numerical data; Genetic Profile; Genome-Wide Association Study; Humans; Leukocyte Count; Male; Neutropenia - diagnosis; Neutropenia - ethnology; Neutropenia - genetics; Polymorphism, Single Nucleotide; Receptors, Cell Surface - genetics; United States - epidemiology; Unnecessary Procedures - methods; Unnecessary Procedures - statistics & numerical data; United States

Up to two-thirds of African American individuals carry the benign rs2814778-CC genotype that lowers total white blood cell (WBC) count. To examine whether the rs2814778-CC genotype is associated with an increased likelihood of receiving a bone marrow biopsy (BMB) for an isolated low WBC count. This...