Human Organoids: Tools for Understanding Biology and Treating Diseases

• Published in: Annual review of pathology Vol. 15; p. 211
• Main Authors: Schutgens, Frans, Clevers, Hans
• Format: Journal Article
• Language: English
• Published: United States 24.01.2020
• Subjects: Adult; Adult Stem Cells - physiology; Cell Biology - trends; Cell- and Tissue-Based Therapy - methods; Cell- and Tissue-Based Therapy - trends; Disease - etiology; Humans; Organoids - cytology; Organoids - physiology; Pluripotent Stem Cells - physiology; Regenerative Medicine - methods; model system; adult stem cell; biobank; organoids; personalized medicine

Organoids are in vitro-cultured three-dimensional structures that recapitulate key aspects of in vivo organs. They can be established from pluripotent stem cells and from adult stem cells, the latter being the subject of this review. Organoids derived from adult stem cells exploit the tissue regener...