Application of Polyethylene Glycol to Promote Cellular Biocompatibility of Polyhydroxybutyrate Films
Polyhydroxybutyrate (PHB) is a biomaterial with potential for applications in biomedical and tissue engineering; however, its brittle nature and high crystallinity limit its potential. Blending PHB with a variety of PEGs produced natural-synthetic composite films composed of FDA-approved polymers wi...
Saved in:
Published in | International Journal of Polymer Science Vol. 2011; no. 2011; pp. 176 - 184 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Cairo, Egypt
Hindawi Limiteds
01.01.2011
Hindawi Puplishing Corporation Hindawi Publishing Corporation Hindawi Limited |
Online Access | Get full text |
Cover
Loading…
Abstract | Polyhydroxybutyrate (PHB) is a biomaterial with potential for applications in biomedical and tissue engineering; however, its brittle nature and high crystallinity limit its potential. Blending PHB with a variety of PEGs produced natural-synthetic composite films composed of FDA-approved polymers with significant reductions in crystallinity, from 70.1% for PHB films to 41.5% for its composite with a 30% (w/w) loading of PEG2000. Blending also enabled manipulation of the material properties, increasing film flexibility with an extension to break of 2.49±1.01% for PHB films and 8.32±1.06% for films containing 30% (w/w) PEG106. Significant changes in the film surface properties, as measured by porosity, contact angles, and water uptake, were also determined as a consequence of the blending process, and these supported greater adhesion and proliferation of neural-associated olfactory ensheathing cells (OECs). A growth rate of 7.2×105 cells per day for PHB films with 30% (w/w) PEG2000 loading compared to 2.5×105 for PHB films was observed. Furthermore, while cytotoxicity of the films as measured by lactate dehydrogenase release was unaffected, biocompatibility, as measured by mitochondrial activity, was found to increase. It is anticipated that fine control of PEG composition in PHB-based composite biomaterials can be utilised to support their applications in medicinal and tissue engineering applications. |
---|---|
AbstractList | Polyhydroxybutyrate (PHB) is a biomaterial with potential for applications in biomedical and tissue engineering; however, its brittle nature and high crystallinity limit its potential. Blending PHB with a variety of PEGs produced natural-synthetic composite films composed of FDA-approved polymers with significant reductions in crystallinity, from 70.1% for PHB films to 41.5% for its composite with a 30% (w/w) loading of PEG2000. Blending also enabled manipulation of the material properties, increasing film flexibility with an extension to break of 2.49±1.01% for PHB films and 8.32±1.06% for films containing 30% (w/w) PEG106. Significant changes in the film surface properties, as measured by porosity, contact angles, and water uptake, were also determined as a consequence of the blending process, and these supported greater adhesion and proliferation of neural-associated olfactory ensheathing cells (OECs). A growth rate of 7.2×105 cells per day for PHB films with 30% (w/w) PEG2000 loading compared to 2.5×105 for PHB films was observed. Furthermore, while cytotoxicity of the films as measured by lactate dehydrogenase release was unaffected, biocompatibility, as measured by mitochondrial activity, was found to increase. It is anticipated that fine control of PEG composition in PHB-based composite biomaterials can be utilised to support their applications in medicinal and tissue engineering applications. Polyhydroxybutyrate (PHB) is a biomaterial with potential for applications in biomedical and tissue engineering; however, its brittle nature and high crystallinity limit its potential. Blending PHB with a variety of PEGs produced natural-synthetic composite films composed of FDA-approved polymers with significant reductions in crystallinity, from 70.1% for PHB films to 41.5% for its composite with a 30% (w/w) loading of PEG2000. Blending also enabled manipulation of the material properties, increasing film flexibility with an extension to break of 2.49 ± 1.01% for PHB films and 8.32 ± 1.06% for films containing 30% (w/w) PEG106. Significant changes in the film surface properties, as measured by porosity, contact angles, and water uptake, were also determined as a consequence of the blending process, and these supported greater adhesion and proliferation of neural-associated olfactory ensheathing cells (OECs). A growth rate of 7.2 × 10 5 cells per day for PHB films with 30% (w/w) PEG2000 loading compared to 2.5 × 10 5 for PHB films was observed. Furthermore, while cytotoxicity of the films as measured by lactate dehydrogenase release was unaffected, biocompatibility, as measured by mitochondrial activity, was found to increase. It is anticipated that fine control of PEG composition in PHB-based composite biomaterials can be utilised to support their applications in medicinal and tissue engineering applications. |
Author | Robert A. Russell Rodman T. H. Chan Peter J. Holden L. John R. Foster Helder Marçal |
Author_xml | – sequence: 1 givenname: Rodman T. H. surname: Chan fullname: Chan, Rodman T. H. organization: Bio/Polymer Research GroupCentre for Advanced Macromolecular DesignSchool of Biotechnology and Biomolecular ScienceUniversity of New South Wales, Sydney, NSW 2052Australiaunsw.edu.au – sequence: 2 givenname: Helder surname: Marçal fullname: Marçal, Helder organization: Bio/Polymer Research GroupCentre for Advanced Macromolecular DesignSchool of Biotechnology and Biomolecular ScienceUniversity of New South Wales, Sydney, NSW 2052Australiaunsw.edu.au – sequence: 3 givenname: Robert A. surname: Russell fullname: Russell, Robert A. organization: Bio/Polymer Research GroupCentre for Advanced Macromolecular DesignSchool of Biotechnology and Biomolecular ScienceUniversity of New South Wales, Sydney, NSW 2052Australiaunsw.edu.au – sequence: 4 givenname: Peter J. surname: Holden fullname: Holden, Peter J. organization: Australian Nuclear Science & Technology OrganisationLucas Heights, Sydney, NSW 2234Australiaansto.gov.au – sequence: 5 givenname: L. John R. surname: Foster fullname: Foster, L. John R. organization: Bio/Polymer Research GroupCentre for Advanced Macromolecular DesignSchool of Biotechnology and Biomolecular ScienceUniversity of New South Wales, Sydney, NSW 2052Australiaunsw.edu.au |
BookMark | eNqFkcFrFDEUh4NUsNaePAtzVrbNSzKTmWNdbC0suAc9h5fJi5uSnSyZWXT-e7MdXehJCLwk73sf4Ze37GJIAzH2HvgNQF3fCg5wq7Tkqn7FLqFp9apTkl-c90K8YdfjGCxXSitQXF8yd3c4xNDjFNJQJV9tU5xp2s2RBqoe4tynWE2p2ua0TxNVa4rxGDFXn0Pq0_5Q5myIYZr_ze5ml9Pv2R6nOWMZuA9xP75jrz3Gka7_1iv24_7L9_XX1ebbw-P6brNC1Yhp5WSH5VkWPRdedqCFE9gK7WTdSW9rSygAqOdcgqKOOtsCkUCtuVaeUF6xx8XrEj6ZQw57zLNJGMzzRco_DeYp9JGMl95xQuccgRJN19mGEwhLhL1voS-uT4urz2kcM_mzD7g55W1OeZsl70J_XOhdGBz-Cv-BPywwFYQ8nuHyK6I99TdLH0MOUzBP6ZiHkpvZFkvDayFLAs9GEKeiueTAy3p5AN0YaJX8Az7Ooac |
CitedBy_id | crossref_primary_10_2174_2210315508666180810145127 crossref_primary_10_1016_j_ijbiomac_2022_04_178 crossref_primary_10_3390_polym13081196 crossref_primary_10_1002_btpr_2855 crossref_primary_10_1155_2014_741408 crossref_primary_10_1002_pat_4351 crossref_primary_10_1016_j_eurpolymj_2021_110824 crossref_primary_10_1007_s10965_024_03947_z crossref_primary_10_1016_j_jddst_2022_103564 crossref_primary_10_1016_j_reactfunctpolym_2015_08_010 crossref_primary_10_1088_2053_1591_abc979 crossref_primary_10_1007_s10856_016_5723_4 crossref_primary_10_1007_s00289_022_04406_9 crossref_primary_10_1016_j_ijpharm_2017_02_004 crossref_primary_10_1007_s13205_019_2017_9 crossref_primary_10_3390_ma16165647 crossref_primary_10_1093_nar_gku677 crossref_primary_10_3390_technologies11020048 crossref_primary_10_1016_j_ijpharm_2016_08_066 crossref_primary_10_1016_j_msec_2020_110799 crossref_primary_10_3390_pharmaceutics9040039 crossref_primary_10_3390_molecules191220580 crossref_primary_10_1016_j_ijbiomac_2020_05_114 crossref_primary_10_1016_j_jenvman_2019_109884 crossref_primary_10_1139_cjc_2020_0087 crossref_primary_10_3390_ma12152429 crossref_primary_10_1016_j_ijbiomac_2021_07_067 |
Cites_doi | 10.1016/S0378-1097(02)00713-9 10.1016/S1369-703X(03)00029-9 10.1002/pi.1994 10.1021/bm060675f 10.1002/jbm.820290211 10.1021/bm0344708 10.1016/S0032-3861(00)00678-9 10.1016/S0169-409X(01)00218-6 10.1016/0142-9612(94)90078-7 10.1016/j.polymdegradstab.2003.11.012 10.1002/app.23135 10.1021/bm800418e 10.1007/s00253-006-0732-8 10.1002/app.21921 10.1002/polb.10742 10.1021/bc00022a008 10.1099/ijs.0.63247-0 10.1002/jctb.1667 10.1016/S0040-4020(97)00958-7 10.1002/(SICI)1097-4636(19990315)44:4<446::AID-JBM11>3.0.CO;2-F 10.1007/s00253-007-0976-y 10.1021/bm1007579 10.1023/A:1004364112658 10.1016/S0142-9612(99)00212-4 10.1016/S0142-9612(01)00405-7 10.1016/0169-409X(95)00092-L 10.1126/science.1165527 10.1093/toxsci/kfi256 10.1016/0142-9612(95)93263-D 10.1007/s10973-005-0069-z 10.1002/app.12359 10.1016/j.jbiotec.2005.09.009 10.1021/bp050044h 10.1016/j.actbio.2009.01.035 10.1002/pi.2682 10.1016/S0141-8130(99)00044-6 10.1016/j.npep.2005.07.004 10.1016/S0142-9612(01)00403-3 10.1007/s00018-004-4026-y 10.1002/jbm.820260607 10.1016/0142-9612(94)90052-3 10.1016/j.biomaterials.2005.04.036 |
ContentType | Journal Article |
Contributor | Chan, Rodman T. H Holden, Peter J Marçal, Helder Russell, Robert A Foster, Leslie John Ray |
Contributor_xml | – sequence: 1 fullname: Chan, Rodman T. H – sequence: 2 fullname: Marçal, Helder – sequence: 3 fullname: Russell, Robert A – sequence: 4 fullname: Holden, Peter J – sequence: 5 fullname: Foster, Leslie John Ray |
Copyright | Copyright © 2011 Rodman T. H. Chan et al. |
Copyright_xml | – notice: Copyright © 2011 Rodman T. H. Chan et al. |
DBID | 188 ADJCN AHFXO RHU RHW RHX AAYXX CITATION DOA |
DOI | 10.1155/2011/473045 |
DatabaseName | Airiti Library الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete Hindawi Publishing Complete Hindawi Publishing Subscription Journals Hindawi Publishing Open Access CrossRef Directory of Open Access Journals |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
Database_xml | – sequence: 1 dbid: RHX name: Hindawi Publishing Open Access url: http://www.hindawi.com/journals/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Physics |
EISSN | 1687-9430 |
Editor | Wang, Shanfeng |
Editor_xml | – sequence: 1 givenname: Shanfeng surname: Wang fullname: Wang, Shanfeng |
EndPage | 184 |
ExternalDocumentID | oai_doaj_org_article_f3fd0eaddde142699b60e12beeacf81c 10_1155_2011_473045 474285 P20160523003_201112_201703010010_201703010010_176_184 |
GroupedDBID | 188 ALMA_UNASSIGNED_HOLDINGS M~E .4S .DC 24P 2UF 3V. 4.4 5VS 8FE 8FG 8R4 8R5 AAFWJ AAJEY ABJCF ABUWG ACIWK ADBBV ADJCN AENEX AFKRA AFPKN AHFXO AINHJ ARCSS BCNDV BENPR BGLVJ BPHCQ C1A CCPQU CNMHZ CVCKV CWDGH CZ9 D1I E3Z EBS EDO EJD GROUPED_DOAJ GX1 H13 HCIFZ IAO IEA IL9 ITC KB. KC. KQ8 ML~ OK1 PDBOC PIMPY PQQKQ PROAC Q2X RHU RHX TR2 TUS UZ4 RHW AAYXX CITATION |
ID | FETCH-LOGICAL-a462t-d39a414baf02f39172d2a827d3593fb5bea211ec00314e9e9b81ee2a77074fea3 |
IEDL.DBID | RHX |
ISSN | 1687-9422 |
IngestDate | Mon Oct 07 19:33:48 EDT 2024 Fri Dec 06 02:31:02 EST 2024 Sun Jun 02 19:06:40 EDT 2024 Tue Nov 26 16:45:34 EST 2024 Tue Oct 01 22:53:21 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2011 |
Language | English |
License | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-a462t-d39a414baf02f39172d2a827d3593fb5bea211ec00314e9e9b81ee2a77074fea3 |
OpenAccessLink | https://dx.doi.org/10.1155/2011/473045 |
PageCount | 9 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_f3fd0eaddde142699b60e12beeacf81c crossref_primary_10_1155_2011_473045 hindawi_primary_10_1155_2011_473045 emarefa_primary_474285 airiti_journals_P20160523003_201112_201703010010_201703010010_176_184 |
PublicationCentury | 2000 |
PublicationDate | 2011-01-01 |
PublicationDateYYYYMMDD | 2011-01-01 |
PublicationDate_xml | – month: 01 year: 2011 text: 2011-01-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | Cairo, Egypt |
PublicationPlace_xml | – name: Cairo, Egypt |
PublicationTitle | International Journal of Polymer Science |
PublicationYear | 2011 |
Publisher | Hindawi Limiteds Hindawi Puplishing Corporation Hindawi Publishing Corporation Hindawi Limited |
Publisher_xml | – name: Hindawi Limiteds – name: Hindawi Puplishing Corporation – name: Hindawi Publishing Corporation – name: Hindawi Limited |
References | (3) 2002; 212 (15) 2006; 101 (41) 1995; 29 (35) 2009; 58 (29) 2005; 39 (11) 2006; 100 (14) 1997; 53 (16) 1998; 14 (22) 1999; 44 (7) 2007; 82 (18) 2007; 75 (31) 1998; 33 (24) 2005; 21 (5) 2001; 53 (17) 2005; 79 (34) 2005; 87 (28) 2005; 88 (1) 2006; 122 (13) 1993; 4 (20) 2004; 5 HarrisJ. M.Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications1992New York, NY, USAPlenum Press (6) 2004; 54 (37) 1999; 25 (43) 2002; 23 (23) 2009; 5 (30) 1994; 15 (33) 1996; 18 (27) 2004; 61 (39) 1994; 15 (21) 2008; 9 (42) 2000; 21 (19) 2007; 74 (36) 2003; 16 (8) 2006; 55 (32) 2003; 89 (44) 2009; 323 (12) 2006; 7 (25) 2002; 23 (26) 2010; 11 (2) 2001; 42 (38) 2005; 26 (45) 2010; 11 (40) 1992; 26 (9) 2005; 43 (4) 1995; 16 22 23 45 24 46 25 47 26 (33) 1998; 33 48 27 28 29 (10) 1992 30 31 32 12 34 35 36 15 37 16 38 39 19 (17) 1998; 14 1 2 3 (14) 2006; 100 4 5 6 (18) 2005; 79 7 8 9 40 41 20 42 43 |
References_xml | – volume: 14 start-page: 95 issue: 1 year: 1998 end-page: 96 ident: 16 article-title: Thermal properties of PHB/PEG blends – volume: 11 start-page: 2707 issue: 10 year: 2010 end-page: 2715 ident: 45 article-title: Polyhydroxybutyrate and its copolymer with polyhydroxyvalerate as biomaterials: influence on progression of stem cell cycle – volume: 87 start-page: 1 issue: 1 year: 2005 end-page: 10 ident: 34 article-title: Centrifugally spun polyhydroxybutyrate fibres: accelerated hydrolytic degradation studies – volume: 43 start-page: 35 issue: 1 year: 2005 end-page: 47 ident: 9 article-title: Thermal behavior and intermolecular interactions in blends of poly(3-hydroxybutyrate) and maleated poly(3-hydroxybutyrate) with chitosan – volume: 44 start-page: 446 issue: 4 year: 1999 end-page: 455 ident: 22 article-title: Poly( -hydroxyl acids)/hydroxyapatite porous composites for bone- tissue engineering. I. Preparation and morphology – volume: 9 start-page: 2719 issue: 10 year: 2008 end-page: 2726 ident: 21 article-title: BioPEGylation of polyhydroxyalkanoates: influence on properties and satellite-stem cell cycle – volume: 100 start-page: 1471 year: 2006 end-page: 1478 ident: 11 article-title: Preparation of cellulose acetate butyrate and poly(ethylene glycol) copolymers to blend with poly(3-hydroxybutyrate) – volume: 18 start-page: 133 issue: 2 year: 1996 end-page: 162 ident: 33 article-title: Biosynthetic polyhydroxyalkanoates and their potential in drug delivery – volume: 7 start-page: 3112 issue: 11 year: 2006 end-page: 3119 ident: 12 article-title: Synthesis, characterization, and morphology studies of biodegradable amphiphilic poly[(R)-3-hydroxybutyrate]-alt-poly(ethylene glycol) multiblock copolymers – volume: 4 start-page: 296 issue: 4 year: 1993 end-page: 299 ident: 13 article-title: Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes – volume: 101 start-page: 2776 issue: 5 year: 2006 end-page: 2783 ident: 15 article-title: Crystallization and melting behavior of blends comprising poly(3-hydroxy butyrate-co-3-hydroxy valerate) and poly(ethylene oxide) – volume: 15 start-page: 278 issue: 4 year: 1994 end-page: 284 ident: 39 article-title: Protein adsorption of poly(ether urethane) surfaces modified by amphiphilic and hydrophilic polymers – volume: 42 start-page: 3455 issue: 8 year: 2001 end-page: 3461 ident: 2 article-title: Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) produced by – volume: 88 start-page: 412 issue: 2 year: 2005 end-page: 419 ident: 28 article-title: In vitro cytotoxicity of nanoparticles in mammalian germline stem cells – volume: 58 start-page: 1442 issue: 12 year: 2009 end-page: 1451 ident: 35 article-title: In vitro hydrolytic degradation of centrifugally spun polyhydroxybutyrate-pectin composite fibres – volume: 53 start-page: 15209 issue: 45 year: 1997 end-page: 15223 ident: 14 article-title: Use of poly(ethylene glycol) to control the end group structure and molecular weight of poly(3-hydroxybutyrate) formed by DSM 1122 – volume: 79 start-page: 379 issue: 2 year: 2005 end-page: 381 ident: 17 article-title: Crystallization on films of PHB/PEG blends evaluation by DSC – volume: 15 start-page: 981 issue: 12 year: 1994 end-page: 984 ident: 30 article-title: Resistance and elasticity of the suture threads employed in cardiac bioprostheses – volume: 33 start-page: 1709 issue: 7 year: 1998 end-page: 1713 ident: 31 article-title: A wide-angle X-ray scattering study of the ageing of poly(hydroxybutyrate) – volume: 75 start-page: 1241 issue: 6 year: 2007 end-page: 1247 ident: 18 article-title: Biosynthesis, properties and potential of natural-synthetic hybrids of polyhydroxyalkanoates and polyethylene glycols – volume: 54 start-page: 2285 issue: 6 year: 2004 end-page: 2289 ident: 6 article-title: Taxonomy of the genus Cupriavidus: a tale of lost and found – volume: 26 start-page: 6565 issue: 33 year: 2005 end-page: 6578 ident: 38 article-title: The application of polyhydroxyalkanoates as tissue engineering materials – volume: 55 start-page: 435 issue: 4 year: 2006 end-page: 440 ident: 8 article-title: Synthesis of polyblends from polypropylene and poly(R,S)- -hydroxybutyrate, and their characterization – volume: 212 start-page: 71 issue: 1 year: 2002 end-page: 75 ident: 3 article-title: Polyhydroxyalkanoate biosynthesis in YS1 – volume: 61 start-page: 1238 issue: 10 year: 2004 end-page: 1245 ident: 27 article-title: Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors – volume: 11 start-page: 2707 issue: 10 year: 2010 end-page: 2715 ident: 26 article-title: Polyhydroxybutyrate and its copolymer with polyhydroxyvalerate as biomaterials: influence on progression of stem cell cycle – volume: 21 start-page: 511 issue: 5 year: 2000 end-page: 520 ident: 42 article-title: PEG-variant biomaterials as selectively adhesive protein templates: model surfaces for controlled cell adhesion and migration – volume: 122 start-page: 453 issue: 4 year: 2006 end-page: 462 ident: 1 article-title: Enzymatic recovery and purification of polyhydroxybutyrate produced by – volume: 23 start-page: 2641 issue: 13 year: 2002 end-page: 2648 ident: 43 article-title: Properties and biocompatibility of chitosan films modified by blending with PEG – volume: 39 start-page: 453 issue: 5 year: 2005 end-page: 459 ident: 29 article-title: Galanin inhibits the proliferation of glial olfactory ensheathing cells – volume: 21 start-page: 959 issue: 3 year: 2005 end-page: 964 ident: 24 article-title: Contact angle, WAXS, and SAXS analysis of poly( -hydroxybutyrate) and poly(ethylene glycol) block copolymers obtained via Azotobacter vinelandii UWD – volume: 89 start-page: 2116 issue: 8 year: 2003 end-page: 2122 ident: 32 article-title: Crystallization behavior, mechanical properties, and environmental biodegradability of poly( -hydroxybutyrate)/cellulose acetate butyrate blends – volume: 5 start-page: 643 issue: 2 year: 2004 end-page: 649 ident: 20 article-title: Biosynthesis of natural-synthetic hybrid copolymers: polyhydroxyoctanoate-diethylene glycol – volume: 25 start-page: 293 issue: 1–3 year: 1999 end-page: 301 ident: 37 article-title: New versatile, elastomeric, degradable polymeric materials for medicine – volume: 16 start-page: 115 issue: 2 year: 2003 end-page: 123 ident: 36 article-title: Effects of surface morphology on the biocompatibility of polyhydroxyalkanoates – volume: 53 start-page: 5 issue: 1 year: 2001 end-page: 21 ident: 5 article-title: Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate – volume: 16 start-page: 341 issue: 4 year: 1995 end-page: 343 ident: 4 article-title: Enzymatic assay of hydroxybutyric acid monomer formation in poly( -hydroxybutyrate) degradation studies – volume: 74 start-page: 1 issue: 1 year: 2007 end-page: 12 ident: 19 article-title: Increased diversification of polyhydroxyalkanoates by modification reactions for industrial and medical applications – volume: 29 start-page: 207 issue: 2 year: 1995 end-page: 215 ident: 41 article-title: Densely crosslinked polymer networks of poly(ethylene glycol) in trimethylolpropane triacrylate for cell-adhesion-resistant surfaces – volume: 5 start-page: 2002 issue: 6 year: 2009 end-page: 2012 ident: 23 article-title: Improving hydrophilicity, mechanical properties and biocompatibility of poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate] through blending with poly[(R)-3-hydroxybutyrate]-alt-poly(ethylene oxide) – volume: 82 start-page: 233 issue: 3 year: 2007 end-page: 247 ident: 7 article-title: Polyhydroxyalkanoates: biodegradable polymers with a range of applications – volume: 23 start-page: 2649 issue: 13 year: 2002 end-page: 2657 ident: 25 article-title: In vitro and in vivo degradation studies for development of a biodegradable patch based on poly(3-hydroxybutyrate) – volume: 26 start-page: 779 issue: 6 year: 1992 end-page: 790 ident: 40 article-title: Reduction of fibrinogen adsorption on PEG-coated polystyrene surfaces – volume: 323 start-page: 802 issue: 5915 year: 2009 end-page: 806 ident: 44 article-title: Axon regeneration requires a conserved MAP kinase pathway – ident: 3 doi: 10.1016/S0378-1097(02)00713-9 – ident: 38 doi: 10.1016/S1369-703X(03)00029-9 – ident: 8 doi: 10.1002/pi.1994 – ident: 12 doi: 10.1021/bm060675f – ident: 43 doi: 10.1002/jbm.820290211 – ident: 22 doi: 10.1021/bm0344708 – ident: 2 doi: 10.1016/S0032-3861(00)00678-9 – ident: 5 doi: 10.1016/S0169-409X(01)00218-6 – ident: 32 doi: 10.1016/0142-9612(94)90078-7 – ident: 36 doi: 10.1016/j.polymdegradstab.2003.11.012 – volume: 100 start-page: 1471 year: 2006 ident: 14 publication-title: Journal of Applied Polymer Science doi: 10.1002/app.23135 – ident: 23 doi: 10.1021/bm800418e – ident: 20 doi: 10.1007/s00253-006-0732-8 – volume: 14 start-page: 95 issue: 1 year: 1998 ident: 17 publication-title: Journal of Materials Science and Technology – ident: 16 doi: 10.1002/app.21921 – ident: 9 doi: 10.1002/polb.10742 – volume: 4 start-page: 296 issue: 4 year: 1993 ident: 13 publication-title: Bioconjugate Chemistry doi: 10.1021/bc00022a008 – ident: 6 doi: 10.1099/ijs.0.63247-0 – ident: 7 doi: 10.1002/jctb.1667 – ident: 15 doi: 10.1016/S0040-4020(97)00958-7 – ident: 24 doi: 10.1002/(SICI)1097-4636(19990315)44:4<446::AID-JBM11>3.0.CO;2-F – ident: 19 doi: 10.1007/s00253-007-0976-y – ident: 31 doi: 10.1021/bm1007579 – volume: 33 start-page: 1709 issue: 7 year: 1998 ident: 33 publication-title: Journal of Materials Science doi: 10.1023/A:1004364112658 – ident: 45 doi: 10.1016/S0142-9612(99)00212-4 – ident: 27 doi: 10.1016/S0142-9612(01)00405-7 – ident: 35 doi: 10.1016/0169-409X(95)00092-L – ident: 47 doi: 10.1126/science.1165527 – ident: 29 doi: 10.1093/toxsci/kfi256 – ident: 4 doi: 10.1016/0142-9612(95)93263-D – volume: 79 start-page: 379 issue: 2 year: 2005 ident: 18 publication-title: Journal of Thermal Analysis and Calorimetry doi: 10.1007/s10973-005-0069-z – ident: 34 doi: 10.1002/app.12359 – ident: 1 doi: 10.1016/j.jbiotec.2005.09.009 – year: 1992 ident: 10 – ident: 48 doi: 10.1021/bm1007579 – ident: 26 doi: 10.1021/bp050044h – ident: 25 doi: 10.1016/j.actbio.2009.01.035 – ident: 37 doi: 10.1002/pi.2682 – ident: 39 doi: 10.1016/S0141-8130(99)00044-6 – ident: 30 doi: 10.1016/j.npep.2005.07.004 – ident: 46 doi: 10.1016/S0142-9612(01)00403-3 – ident: 28 doi: 10.1007/s00018-004-4026-y – ident: 42 doi: 10.1002/jbm.820260607 – ident: 41 doi: 10.1016/0142-9612(94)90052-3 – ident: 40 doi: 10.1016/j.biomaterials.2005.04.036 |
SSID | ssib044741407 ssj0000396624 |
Score | 2.0561795 |
Snippet | Polyhydroxybutyrate (PHB) is a biomaterial with potential for applications in biomedical and tissue engineering; however, its brittle nature and high... |
SourceID | doaj crossref hindawi emarefa airiti |
SourceType | Open Website Aggregation Database Publisher |
StartPage | 176 |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlEOil9BW6bVMEzdWsLcmSdUxCtqHQsocGchOSPSIL7rp0HYL_fWckJ9lc2kvBYGRsIc9D34w0M2LsRIPoajB10YpQFkqXvrBtFIUVHppgbRs0JQp_-64vr9TX6_p676gvignL5YEz4ZZRxq7E30U1rCjt0gZdQiUC4IwRm6pNs28p9pwplCSlECjV7NikOVmiWZ9PuNWoVVYJMSfrIZ4uCQSXytCmIQKR31A5oSc4lcr5p5xdj23EsMMb8pjvNntYtHrJXsxGJD_Ng3_FnsH2NTtMwZzt7g3rTh93pfkQ-XroJ0CGIMAA_9JPyHs-DnydIvGAn0PfUzAqP9sMKSR9zBGz0_23N1NHwS7hdpyosARfbfqfu7fsanXx4_yymE9TKLzSYiw6aT0SJfhYiijRSxOd8I0wnaytjKEO4NEZhJbUXIEFG5oKQHhj0MqI4OURO9gOW3jHuIE2GrSjquiN6nQIHg3HKGQLqN51FRbsIhPRzQqxc2tBpexoCbqUjuhdCbrRfENVoMqnjcpoh67ngp3c88D9ysU3XHJa6jr14TLPFuyM-PPwClXMTg9QjtwsR-5fcrRgRzN3H_pBIRIN9v55ZvbfxvD-f4zhA3uel6zp-sgOxt-3cIw2zxg-JfH-A33P96s priority: 102 providerName: Directory of Open Access Journals |
Title | Application of Polyethylene Glycol to Promote Cellular Biocompatibility of Polyhydroxybutyrate Films |
URI | https://www.airitilibrary.com/Article/Detail/P20160523003-201112-201703010010-201703010010-176-184 https://search.emarefa.net/detail/BIM-474285 https://dx.doi.org/10.1155/2011/473045 https://doaj.org/article/f3fd0eaddde142699b60e12beeacf81c |
Volume | 2011 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1La9wwEBZNINBL6St0-wiC5mpiS7JkHZOw26WQspQG9mYke0QW3HXoOhRf-ts7I2vTpoVSMDYy8mDmoW9GGo0YO9Ug2hJMmTXC55nSuctsE0RmhYPKW9t4TRuFrz7p5bX6uC7XKUF29_cSPqLdGUHUmTK0pHfADipDiVufl-u91iiFoKhSEBPHX4ku_HSarUYLskqItDHvD2oIOm5DpYMeYFIs3R_35zpsI14d3VB0_H3zG-4snrInyWHk55OEn7FHsH3OjmLiZrN7wdrzXyvQvA981XcjIPMRTIB_6EaUMx96vopZd8Avoeso8ZRfbPqYfj5M2bHj_tubsaXEFn83jFREgi823dfdS3a9mH-5XGbp5ITMKS2GrJXWIVO8C7kIEiMy0QpXCdPK0srgSw8OAz9oyKQVWLC-KgCEMwY9igBOHrPDbb-FV4wbaIJBn6kIzqhWe-_QSQxCNoCmXBZ-xuYTE-uk_Lt6JahsHU0357ImfheCHjS2UMWn_GGjMLrGMHPGTvcyqG-nQht1DFDKMtKoJ5nN2AXJ574LVceOL1Bj6mRsdZChzdFEcOguaKuu9TqHQnhAlAlV0czYcZLuPR1UIlEh9fdJ2P_6h9f_1esNezzNP9P1lh0O3-7gHTowgz-JgT_er37MT6Iu_wQNPORb |
link.rule.ids | 314,780,784,863,864,877,878,2102,27924,27925 |
linkProvider | Hindawi Publishing |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Application+of+Polyethylene+Glycol+to+Promote+Cellular+Biocompatibility+of+Polyhydroxybutyrate+Films&rft.jtitle=International+Journal+of+Polymer+Science&rft.au=Rodman+T.+H.+Chan&rft.au=Helder+Mar%C3%A7al&rft.au=Robert+A.+Russell&rft.au=Peter+J.+Holden&rft.date=2011-01-01&rft.pub=Hindawi+Limiteds&rft.issn=1687-9422&rft.volume=2011&rft.spage=176&rft.epage=184&rft_id=info:doi/10.1155%2F2011%2F473045&rft.externalDocID=P20160523003_201112_201703010010_201703010010_176_184 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1687-9422&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1687-9422&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1687-9422&client=summon |