A Double-Blind, Placebo-Controlled Study of the Omega-3 Fatty Acid Docosahexaenoic Acid in the Treatment of Major Depression
OBJECTIVE: This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression. METHOD: Thirty-six depressed patients were randomly assigned to receive DHA, 2 g day, or placebo for 6 weeks. Response was defined a priori as a ≥50% reduction in the s...
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| Published in | The American journal of psychiatry Vol. 160; no. 5; pp. 996 - 998 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Psychiatric Publishing
01.05.2003
American Psychiatric Association |
| Subjects | |
| Online Access | Get full text |
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| Abstract | OBJECTIVE: This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression. METHOD: Thirty-six depressed patients were randomly assigned to receive DHA, 2 g day, or placebo for 6 weeks. Response was defined a priori as a ≥50% reduction in the score on the Montgomery-Åsberg Depression Rating Scale. Thirty-five participants were evaluable; 18 received DHA, and 17 received placebo. RESULTS: Response rates were 27.8% in the DHA group and 23.5% in the placebo group. The difference in response rates between groups did not reach statistical significance. CONCLUSIONS: This trial failed to show a significant effect of DHA monotherapy in subjects with major depression. |
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| AbstractList | This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression.OBJECTIVEThis study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression.Thirty-six depressed patients were randomly assigned to receive DHA, 2 g/day, or placebo for 6 weeks. Response was defined a priori as a > or =50% reduction in the score on the Montgomery-Asberg Depression Rating Scale. Thirty-five participants were evaluable; 18 received DHA, and 17 received placebo.METHODThirty-six depressed patients were randomly assigned to receive DHA, 2 g/day, or placebo for 6 weeks. Response was defined a priori as a > or =50% reduction in the score on the Montgomery-Asberg Depression Rating Scale. Thirty-five participants were evaluable; 18 received DHA, and 17 received placebo.Response rates were 27.8% in the DHA group and 23.5% in the placebo group. The difference in response rates between groups did not reach statistical significance.RESULTSResponse rates were 27.8% in the DHA group and 23.5% in the placebo group. The difference in response rates between groups did not reach statistical significance.This trial failed to show a significant effect of DHA monotherapy in subjects with major depression.CONCLUSIONSThis trial failed to show a significant effect of DHA monotherapy in subjects with major depression. OBJECTIVE: This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression. METHOD: Thirty-six depressed patients were randomly assigned to receive DHA, 2 g day, or placebo for 6 weeks. Response was defined a priori as a ≥50% reduction in the score on the Montgomery-Åsberg Depression Rating Scale. Thirty-five participants were evaluable; 18 received DHA, and 17 received placebo. RESULTS: Response rates were 27.8% in the DHA group and 23.5% in the placebo group. The difference in response rates between groups did not reach statistical significance. CONCLUSIONS: This trial failed to show a significant effect of DHA monotherapy in subjects with major depression. This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression. Thirty-six depressed patients were randomly assigned to receive DHA, 2 g/day, or placebo for 6 weeks. Response was defined a priori as a > or =50% reduction in the score on the Montgomery-Asberg Depression Rating Scale. Thirty-five participants were evaluable; 18 received DHA, and 17 received placebo. Response rates were 27.8% in the DHA group and 23.5% in the placebo group. The difference in response rates between groups did not reach statistical significance. This trial failed to show a significant effect of DHA monotherapy in subjects with major depression. This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major decosahexaenoic acid for the treatment of major depression. Thirty-six depressed patients were randomly assigned to receive DHA, 2 g/day, or placebo for 6 weeks. Response rates were 27.8% in the DHA group and 23.5% in the placebo group. This trial failed to show a significant effect of DHA monotherapy in subjects with major depression. [Publication abstract] |
| Author | Zboyan, Holly A. Kertz, Barbara Puryear, Lucy J. Marangell, Lauren B. Kim, H. Florence Seung Martinez, James M. |
| Author_xml | – sequence: 1 givenname: Lauren B. surname: Marangell fullname: Marangell, Lauren B. – sequence: 2 givenname: James M. surname: Martinez fullname: Martinez, James M. – sequence: 3 givenname: Holly A. surname: Zboyan fullname: Zboyan, Holly A. – sequence: 4 givenname: Barbara surname: Kertz fullname: Kertz, Barbara – sequence: 5 givenname: H. Florence Seung surname: Kim fullname: Kim, H. Florence Seung – sequence: 6 givenname: Lucy J. surname: Puryear fullname: Puryear, Lucy J. |
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| Snippet | OBJECTIVE: This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression. METHOD: Thirty-six... This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression. Thirty-six depressed patients were... This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major decosahexaenoic acid for the treatment of major... This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression.OBJECTIVEThis study was an evaluation... |
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| SubjectTerms | Adolescent Adult Biological and medical sciences Depressive Disorder - diagnosis Depressive Disorder - drug therapy Depressive Disorder - psychology Docosahexaenoic Acids - therapeutic use Double-Blind Method Fatty acids Female Humans Male Medical sciences Mental depression Middle Aged Neuropharmacology Outcome Assessment (Health Care) Pharmacology. Drug treatments Placebos Psychiatric Status Rating Scales Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Treatment Outcome |
| Title | A Double-Blind, Placebo-Controlled Study of the Omega-3 Fatty Acid Docosahexaenoic Acid in the Treatment of Major Depression |
| URI | http://dx.doi.org/10.1176/appi.ajp.160.5.996 https://www.ncbi.nlm.nih.gov/pubmed/12727707 https://www.proquest.com/docview/220478383 https://www.proquest.com/docview/73245955 |
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