IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication

• Published in: Journal of virology Vol. 95; no. 20; p. e0083721
• Main Authors: Meischel, Tina, Fritzlar, Svenja, Villalon-Letelier, Fernando, Tessema, Melkamu B, Brooks, Andrew G, Reading, Patrick C, Londrigan, Sarah L
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 27.09.2021
• Subjects: A549 Cells; Antigens, Differentiation - metabolism; Cell Line, Tumor; Cell Membrane - metabolism; Endocytosis - physiology; Host-Pathogen Interactions - physiology; Humans; Influenza A virus - metabolism; Influenza A virus - pathogenicity; Interferons - metabolism; Membrane Proteins - metabolism; Parainfluenza Virus 3, Human - metabolism; Parainfluenza Virus 3, Human - pathogenicity; RNA-Binding Proteins - metabolism; Virology; Virus Diseases - metabolism; Virus Internalization; Virus Replication - physiology; Virus-Cell Interactions; IFITM; influenza; host restriction factors; parainfluenza virus

Interferon-induced transmembrane (IFITM) proteins inhibit a broad range of enveloped viruses by blocking entry into host cells. We used an inducible overexpression system to investigate if IFITM1, IFITM2, and IFITM3 could modulate early and/or late stages of influenza A virus (IAV) or parainfluenza...