Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice

• Published in: Journal of virology Vol. 95; no. 17; p. e0040221
• Main Authors: Silvas, Jesus A., Vasquez, Desarey Morales, Park, Jun-Gyu, Chiem, Kevin, Allué-Guardia, Anna, Garcia-Vilanova, Andreu, Platt, Roy Neal, Miorin, Lisa, Kehrer, Thomas, Cupic, Anastasija, Gonzalez-Reiche, Ana S., Bakel, Harm van, García-Sastre, Adolfo, Anderson, Tim, Torrelles, Jordi B., Ye, Chengjin, Martinez-Sobrido, Luis
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 10.08.2021
• Subjects: Pathogenesis and Immunity; COVID-19; ORF8; ORF7b; pathogenesis; SARS-CoV-2; ORF7a; ORF6; ORF3a; K18 hACE2 transgenic mice; hACE2

Despite great efforts put forward worldwide to combat the current coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a human health and socioeconomic threat. Insights into the pathogenesis of SARS-CoV-2 and the contribution of v...