An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

• Published in: Journal of the American Chemical Society Vol. 139; no. 26; pp. 8808 - 8811
• Main Authors: Lozano-Torres, Beatriz, Galiana, Irene, Rovira, Miguel, Garrido, Eva, Chaib, Selim, Bernardos, Andrea, Muñoz-Espín, Daniel, Serrano, Manuel, Martínez-Máñez, Ramón, Sancenón, Félix
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 05.07.2017; Amer Chemical Soc
• Subjects: Animals; cell senescence; Cellular Senescence - drug effects; Chemistry; Chemistry, Multidisciplinary; drug therapy; emissions factor; fluorescence; fluorescent dyes; Fluorescent Dyes - chemistry; galactose; histidine; Humans; Mice; Naphthalimides - chemistry; Neoplasms - drug therapy; nitrogen; Photons; Physical Sciences; Reference Standards; Science & Technology; Xenograft Model Antitumor Assays; VISUALIZATION; TUMOR; DESIGN; BETA-GALACTOSIDASE ACTIVITY; LIVING CELLS; SCAFFOLD

A naphthalimide-based two-photon probe (AHGa) for the detection of cell senescence is designed. The probe contains a naphthalimide core, an l-histidine methyl ester linker, and an acetylated galactose bonded to one of the aromatic nitrogen atoms of the l-histidine through a hydrolyzable N-glycosidic...