Biological Photothermal Nanodots Based on Self-Assembly of Peptide–Porphyrin Conjugates for Antitumor Therapy

• Published in: Journal of the American Chemical Society Vol. 139; no. 5; pp. 1921 - 1927
• Main Authors: Zou, Qianli, Abbas, Manzar, Zhao, Luyang, Li, Shukun, Shen, Guizhi, Yan, Xuehai
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.02.2017
• Subjects: acoustics; Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; biocompatible materials; Cell Proliferation - drug effects; Cell Survival - drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; energy; Female; harvesting; heat; Humans; hydrophilic interactions; image analysis; Mammary Neoplasms, Experimental - drug therapy; Mammary Neoplasms, Experimental - pathology; MCF-7 Cells; Mice; Molecular Structure; nanomaterials; Nanostructures - chemistry; Particle Size; Peptides - chemistry; Peptides - pharmacology; Photochemical Processes; Phototherapy; polypeptides; porphyrins; Porphyrins - chemistry; Porphyrins - pharmacology; Structure-Activity Relationship; Surface Properties; therapeutics; thermography; tissues

Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy...