Biological Photothermal Nanodots Based on Self-Assembly of Peptide–Porphyrin Conjugates for Antitumor Therapy
Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy...
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| Published in | Journal of the American Chemical Society Vol. 139; no. 5; pp. 1921 - 1927 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
08.02.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of J-aggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots. The peptide moieties not only provide aqueous stability for the nanodots through hydrophilic interactions, but also provide a spatial barrier between porphyrin groups to inhibit the further growth of nanodots through the strong π-stacking interactions. Thermographic imaging reveals that the conversion of light to heat based on the nanodots is efficient in vitro and in vivo, enabling the nanodots to be applied for photothermal acoustic imaging and antitumor therapy. Antitumor therapy results show that these nanodots are highly biocompatible photothermal agents for tumor ablation, demonstrating the feasibility of using bioinspired nanostructures of self-assembling biomaterials for biomedical photoactive applications. |
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| AbstractList | Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of J-aggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots. The peptide moieties not only provide aqueous stability for the nanodots through hydrophilic interactions, but also provide a spatial barrier between porphyrin groups to inhibit the further growth of nanodots through the strong π-stacking interactions. Thermographic imaging reveals that the conversion of light to heat based on the nanodots is efficient in vitro and in vivo, enabling the nanodots to be applied for photothermal acoustic imaging and antitumor therapy. Antitumor therapy results show that these nanodots are highly biocompatible photothermal agents for tumor ablation, demonstrating the feasibility of using bioinspired nanostructures of self-assembling biomaterials for biomedical photoactive applications. Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of J-aggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots. The peptide moieties not only provide aqueous stability for the nanodots through hydrophilic interactions, but also provide a spatial barrier between porphyrin groups to inhibit the further growth of nanodots through the strong π-stacking interactions. Thermographic imaging reveals that the conversion of light to heat based on the nanodots is efficient in vitro and in vivo, enabling the nanodots to be applied for photothermal acoustic imaging and antitumor therapy. Antitumor therapy results show that these nanodots are highly biocompatible photothermal agents for tumor ablation, demonstrating the feasibility of using bioinspired nanostructures of self-assembling biomaterials for biomedical photoactive applications.Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of J-aggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots. The peptide moieties not only provide aqueous stability for the nanodots through hydrophilic interactions, but also provide a spatial barrier between porphyrin groups to inhibit the further growth of nanodots through the strong π-stacking interactions. Thermographic imaging reveals that the conversion of light to heat based on the nanodots is efficient in vitro and in vivo, enabling the nanodots to be applied for photothermal acoustic imaging and antitumor therapy. Antitumor therapy results show that these nanodots are highly biocompatible photothermal agents for tumor ablation, demonstrating the feasibility of using bioinspired nanostructures of self-assembling biomaterials for biomedical photoactive applications. |
| Author | Zou, Qianli Yan, Xuehai Li, Shukun Shen, Guizhi Zhao, Luyang Abbas, Manzar |
| AuthorAffiliation | Center for Mesoscience, Institute of Process Engineering State Key Laboratory of Biochemical Engineering, Institute of Process Engineering University of Chinese Academy of Sciences |
| AuthorAffiliation_xml | – name: University of Chinese Academy of Sciences – name: Center for Mesoscience, Institute of Process Engineering – name: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering |
| Author_xml | – sequence: 1 givenname: Qianli orcidid: 0000-0003-0464-4156 surname: Zou fullname: Zou, Qianli organization: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering – sequence: 2 givenname: Manzar surname: Abbas fullname: Abbas, Manzar organization: University of Chinese Academy of Sciences – sequence: 3 givenname: Luyang surname: Zhao fullname: Zhao, Luyang organization: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering – sequence: 4 givenname: Shukun surname: Li fullname: Li, Shukun organization: University of Chinese Academy of Sciences – sequence: 5 givenname: Guizhi surname: Shen fullname: Shen, Guizhi organization: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering – sequence: 6 givenname: Xuehai orcidid: 0000-0002-0890-0340 surname: Yan fullname: Yan, Xuehai email: yanxh@ipe.ac.cn organization: Center for Mesoscience, Institute of Process Engineering |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28103663$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | acoustics Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology biocompatible materials Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor energy Female harvesting heat Humans hydrophilic interactions image analysis Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - pathology MCF-7 Cells Mice Molecular Structure nanomaterials Nanostructures - chemistry Particle Size Peptides - chemistry Peptides - pharmacology Photochemical Processes Phototherapy polypeptides porphyrins Porphyrins - chemistry Porphyrins - pharmacology Structure-Activity Relationship Surface Properties therapeutics thermography tissues |
| Title | Biological Photothermal Nanodots Based on Self-Assembly of Peptide–Porphyrin Conjugates for Antitumor Therapy |
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