Engineering Intracellular Delivery Nanocarriers and Nanoreactors from Oxidation-Responsive Polymersomes via Synchronized Bilayer Cross-Linking and Permeabilizing Inside Live Cells

• Published in: Journal of the American Chemical Society Vol. 138; no. 33; pp. 10452 - 10466
• Main Authors: Deng, Zhengyu, Qian, Yinfeng, Yu, Yongqiang, Liu, Guhuan, Hu, Jinming, Zhang, Guoying, Liu, Shiyong
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 24.08.2016; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Multidisciplinary; composite polymers; crosslinking; drug therapy; drugs; encapsulation; engineering; fluorescence; hydrogen peroxide; hydrophilicity; hydrophobicity; image analysis; membrane permeability; micelles; nanocarriers; nanomedicine; oxidation; oxidative stress; peptides; Physical Sciences; Science & Technology; POLYPRODRUG AMPHIPHILES; NANOPARTICLES; AMPLIFICATION; PRODRUG; VESICLES; CHEMISTRY; HYDROGEN-PEROXIDE; BLOCK-COPOLYMER; TUMORS; TRIGGERED DRUG-RELEASE

Reactive oxygen species (ROS) and oxidative stress are implicated in various physiological and pathological processes, and this feature provides a vital biochemical basis for designing novel therapeutic and diagnostic nanomedicines. Among them, oxidation-responsive micelles and vesicles (polymersome...