Remote Cooperative Group Strategy Enables Ligands for Accelerative Asymmetric Gold Catalysis

• Published in: Journal of the American Chemical Society Vol. 139; no. 45; pp. 16064 - 16067
• Main Authors: Wang, Zhixun, Nicolini, Corrado, Hervieu, Cedric, Wong, Yuk-Fai, Zanoni, Giuseppe, Zhang, Liming
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 15.11.2017; Amer Chemical Soc
• Subjects: Alkadienes - chemical synthesis; Alkadienes - chemistry; allene; Amides - chemistry; Catalysis; catalysts; catalytic activity; Chemistry; Chemistry, Multidisciplinary; enantiomers; enantioselectivity; gold; Gold - chemistry; Ligands; Molecular Structure; Naphthalenes - chemistry; Physical Sciences; Science & Technology; stereochemistry; TRANSITION-METAL CATALYSIS; COMPLEXES; HYDROALKOXYLATION; ESTERS; TRANSFER HYDROGENATION; ALDEHYDES; ALLENES

An accelerative asymmetric gold catalysis is achieved for the first time via chiral ligand metal cooperation. An asymmetrically positioned remote amide group in the designed chiral binaphthyl-based ligand plays the essential role of a general base catalyst and selectively accelerates the cyclization...