Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α‑Glucosidase

Sixteen new lanostane triterpenes, ganoleucoins A–P (1–16), together with 10 known tripterpenes (17–26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spec...

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Published inJournal of natural products (Washington, D.C.) Vol. 78; no. 8; pp. 1977 - 1989
Main Authors Wang, Kai, Bao, Li, Xiong, Weiping, Ma, Ke, Han, Junjie, Wang, Wenzhao, Yin, Wenbing, Liu, Hongwei
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 28.08.2015
Amer Chemical Soc
Subjects
Acyl Coenzyme A - drug effects
Agaricales - chemistry
alpha-glucosidase
alpha-Glucosidases - drug effects
Chemistry, Medicinal
cytotoxicity
fruiting bodies
Fruiting Bodies, Fungal - chemistry
Ganoderma
Ganoderma - chemistry
Ganoderma lucidum
Glycoside Hydrolase Inhibitors - chemistry
Glycoside Hydrolase Inhibitors - isolation & purification
Glycoside Hydrolase Inhibitors - pharmacology
Humans
Hydroxymethylglutaryl CoA Reductases - drug effects
hydroxymethylglutaryl-CoA reductases
Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent - drug effects
Inhibitory Concentration 50
K562 Cells
Life Sciences & Biomedicine
medicinal fungi
Molecular Structure
paclitaxel
Paclitaxel - pharmacology
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
secondary metabolites
spectral analysis
Tibet
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoids
yeasts
Tibet
CANCER-CELLS
GLYCOSIDES
APOPTOSIS
SINENSE
ACID
METAANALYSIS
CORDYCEPS
LUCIDUM
CYTOTOXICITY
CONSTITUENTS
Online AccessGet full text
ISSN0163-3864
1520-6025
1520-6025
DOI10.1021/acs.jnatprod.5b00331

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Abstract Sixteen new lanostane triterpenes, ganoleucoins A–P (1–16), together with 10 known tripterpenes (17–26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1–26 on HMG-CoA reductase and α-glucosidase were tested in vitro. Compounds 1, 3, 6, 10–14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against α-glucosidase from yeast with IC50 values of 13.6, 2.5, and 5.9 μM, respectively. In addition, the cytotoxicity of 1–26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC50 values in the range 10–20 μM. Paclitaxel was used as the positive control with an IC50 value of 0.9 μM. This is the first report of secondary metabolites from this medicinal mushroom.
AbstractList Sixteen new lanostane triterpenes, ganoleucoins A-P (1-16), together with 10 known tripterpenes (17-26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1-26 on HMG-CoA reductase and a-glucosidase were tested in vitro. Compounds 1, 3, 6, 10-14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against a-glucosidase from yeast with IC50 values of 13.6, 2.5, and 5.9 mu M, respectively. In addition, the cytotoxicity of 1-26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC50 values in the range 10-20 mu M. Paclitaxel was used as the positive control with an IC50 value of 0.9 mu M. This is the first report of secondary metabolites from this medicinal mushroom.
Sixteen new lanostane triterpenes, ganoleucoins A-P (1-16), together with 10 known tripterpenes (17-26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1-26 on HMG-CoA reductase and α-glucosidase were tested in vitro. Compounds 1, 3, 6, 10-14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against α-glucosidase from yeast with IC₅₀ values of 13.6, 2.5, and 5.9 μM, respectively. In addition, the cytotoxicity of 1-26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC₅₀ values in the range 10-20 μM. Paclitaxel was used as the positive control with an IC₅₀ value of 0.9 μM. This is the first report of secondary metabolites from this medicinal mushroom.
Sixteen new lanostane triterpenes, ganoleucoins A-P (1-16), together with 10 known tripterpenes (17-26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1-26 on HMG-CoA reductase and alpha -glucosidase were tested in vitro. Compounds 1, 3, 6, 10-14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against alpha -glucosidase from yeast with IC sub(50) values of 13.6, 2.5, and 5.9 mu M, respectively. In addition, the cytotoxicity of 1-26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC sub(50) values in the range 10-20 mu M. Paclitaxel was used as the positive control with an IC sub(50) value of 0.9 mu M. This is the first report of secondary metabolites from this medicinal mushroom.
Sixteen new lanostane triterpenes, ganoleucoins A–P (1–16), together with 10 known tripterpenes (17–26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1–26 on HMG-CoA reductase and α-glucosidase were tested in vitro. Compounds 1, 3, 6, 10–14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against α-glucosidase from yeast with IC50 values of 13.6, 2.5, and 5.9 μM, respectively. In addition, the cytotoxicity of 1–26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC50 values in the range 10–20 μM. Paclitaxel was used as the positive control with an IC50 value of 0.9 μM. This is the first report of secondary metabolites from this medicinal mushroom.
Sixteen new lanostane triterpenes, ganoleucoins A-P (1-16), together with 10 known tripterpenes (17-26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1-26 on HMG-CoA reductase and α-glucosidase were tested in vitro. Compounds 1, 3, 6, 10-14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against α-glucosidase from yeast with IC₅₀ values of 13.6, 2.5, and 5.9 μM, respectively. In addition, the cytotoxicity of 1-26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC₅₀ values in the range 10-20 μM. Paclitaxel was used as the positive control with an IC₅₀ value of 0.9 μM. This is the first report of secondary metabolites from this medicinal mushroom.Sixteen new lanostane triterpenes, ganoleucoins A-P (1-16), together with 10 known tripterpenes (17-26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1-26 on HMG-CoA reductase and α-glucosidase were tested in vitro. Compounds 1, 3, 6, 10-14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against α-glucosidase from yeast with IC₅₀ values of 13.6, 2.5, and 5.9 μM, respectively. In addition, the cytotoxicity of 1-26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC₅₀ values in the range 10-20 μM. Paclitaxel was used as the positive control with an IC₅₀ value of 0.9 μM. This is the first report of secondary metabolites from this medicinal mushroom.
Author Ma, Ke
Liu, Hongwei
Bao, Li
Yin, Wenbing
Wang, Wenzhao
Wang, Kai
Xiong, Weiping
Han, Junjie
AuthorAffiliation Chinese Academy of Sciences
Tibet Academy of Agriculture and Animal Science
Institute of Vegetable Research
State Key Laboratory of Mycology, Institute of Microbiology
University of Chinese Academy of Sciences
AuthorAffiliation_xml – name: Tibet Academy of Agriculture and Animal Science
– name: University of Chinese Academy of Sciences
– name: Institute of Vegetable Research
– name: Chinese Academy of Sciences
– name: State Key Laboratory of Mycology, Institute of Microbiology
Author_xml – sequence: 1
  givenname: Kai
  surname: Wang
  fullname: Wang, Kai
– sequence: 2
  givenname: Li
  surname: Bao
  fullname: Bao, Li
– sequence: 3
  givenname: Weiping
  surname: Xiong
  fullname: Xiong, Weiping
– sequence: 4
  givenname: Ke
  surname: Ma
  fullname: Ma, Ke
– sequence: 5
  givenname: Junjie
  surname: Han
  fullname: Han, Junjie
– sequence: 6
  givenname: Wenzhao
  surname: Wang
  fullname: Wang, Wenzhao
– sequence: 7
  givenname: Wenbing
  surname: Yin
  fullname: Yin, Wenbing
– sequence: 8
  givenname: Hongwei
  surname: Liu
  fullname: Liu, Hongwei
  email: liuhw@im.ac.cn
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26287401$$D View this record in MEDLINE/PubMed
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PublicationYear 2015
Publisher American Chemical Society and American Society of Pharmacognosy
Amer Chemical Soc
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SSID ssj0003095
Score 2.4709156
Snippet Sixteen new lanostane triterpenes, ganoleucoins A–P (1–16), together with 10 known tripterpenes (17–26), were isolated from the cultivated fruiting bodies of...
Sixteen new lanostane triterpenes, ganoleucoins A-P (1-16), together with 10 known tripterpenes (17-26), were isolated from the cultivated fruiting bodies of...
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StartPage 1977
SubjectTerms Acyl Coenzyme A - drug effects
Agaricales - chemistry
alpha-glucosidase
alpha-Glucosidases - drug effects
Chemistry, Medicinal
cytotoxicity
fruiting bodies
Fruiting Bodies, Fungal - chemistry
Ganoderma
Ganoderma - chemistry
Ganoderma lucidum
Glycoside Hydrolase Inhibitors - chemistry
Glycoside Hydrolase Inhibitors - isolation & purification
Glycoside Hydrolase Inhibitors - pharmacology
Humans
Hydroxymethylglutaryl CoA Reductases - drug effects
hydroxymethylglutaryl-CoA reductases
Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent - drug effects
Inhibitory Concentration 50
K562 Cells
Life Sciences & Biomedicine
medicinal fungi
Molecular Structure
paclitaxel
Paclitaxel - pharmacology
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
secondary metabolites
spectral analysis
Tibet
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoids
yeasts
Title Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α‑Glucosidase
URI http://dx.doi.org/10.1021/acs.jnatprod.5b00331
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https://www.ncbi.nlm.nih.gov/pubmed/26287401
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https://www.proquest.com/docview/1746874543
https://www.proquest.com/docview/2000457688
Volume 78
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