Neurocognitive signs in prodromal Huntington disease

• Published in: Neuropsychology Vol. 25; no. 1; p. 1
• Main Authors: Stout, Julie C, Paulsen, Jane S, Queller, Sarah, Solomon, Andrea C, Whitlock, Kathryn B, Campbell, J Colin, Carlozzi, Noelle, Duff, Kevin, Beglinger, Leigh J, Langbehn, Douglas R, Johnson, Shannon A, Biglan, Kevin M, Aylward, Elizabeth H
• Format: Journal Article
• Language: English
• Published: United States 01.01.2011
• Subjects: Adult; Attention; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Cognition Disorders - genetics; Emotions; Female; Humans; Huntingtin Protein; Huntington Disease - complications; Huntington Disease - diagnosis; Huntington Disease - genetics; International Cooperation; Language; Male; Mental Recall; Middle Aged; Nerve Tissue Proteins - genetics; Neuropsychological Tests; Nuclear Proteins - genetics; Predictive Value of Tests; Psychomotor Performance; Retrospective Studies; Sample Size; Sensitivity and Specificity; Severity of Illness Index; Time Factors; Trinucleotide Repeats - genetics

PREDICT-HD is a large-scale international study of people with the Huntington disease (HD) CAG-repeat expansion who are not yet diagnosed with HD. The objective of this study was to determine the stage in the HD prodrome at which cognitive differences from CAG-normal controls can be reliably detecte...