Biomineralized Metal–Organic Framework Nanoparticles Enable Intracellular Delivery and Endo-Lysosomal Release of Native Active Proteins

• Published in: Journal of the American Chemical Society Vol. 140; no. 31; pp. 9912 - 9920
• Main Authors: Chen, Ting-Ting, Yi, Jin-Tao, Zhao, Yan-Yan, Chu, Xia
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.08.2018
• Subjects: biomimetics; coatings; coordination polymers; encapsulation; mineralization; nanoparticles; precision medicine; proteins

Efficient delivery and endo-lysosomal release of active proteins in living cells remain a challenge in protein-based theranostics. We report a novel protein delivery platform using protein-encapsulating biomineralized metal–organic framework (MOF) nanoparticles (NPs). This platform introduces an ada...