Biomineralized Metal–Organic Framework Nanoparticles Enable Intracellular Delivery and Endo-Lysosomal Release of Native Active Proteins
Efficient delivery and endo-lysosomal release of active proteins in living cells remain a challenge in protein-based theranostics. We report a novel protein delivery platform using protein-encapsulating biomineralized metal–organic framework (MOF) nanoparticles (NPs). This platform introduces an ada...
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| Published in | Journal of the American Chemical Society Vol. 140; no. 31; pp. 9912 - 9920 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
08.08.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Efficient delivery and endo-lysosomal release of active proteins in living cells remain a challenge in protein-based theranostics. We report a novel protein delivery platform using protein-encapsulating biomineralized metal–organic framework (MOF) nanoparticles (NPs). This platform introduces an adapted biomimetic mineralization method for facile synthesis of MOF NPs with high protein encapsulation efficiency and a new polymer coating strategy to confer the NPs with long-term stability. In vitro results show that protein-encapsulating MOF NPs have the advantages of preserving protein activity for months and protecting proteins from enzyme-mediated degradation. Live cell studies reveal that MOF NPs enable rapid cellular uptake, efficient release and escape of proteins from endo-lysosomes, and preservation of protein activity in living cells. Moreover, the developed platform is demonstrated to enable easy encapsulation of multiple proteins in single MOF NPs for efficient protein co-delivery. To our knowledge, it is the first time that protein-encapsulating MOF NPs have been developed as a generally applicable strategy for intracellular delivery of native active proteins. The developed protein-encapsulating biomineralized MOF NPs can provide a valuable platform for protein-based theranostic applications. |
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| AbstractList | Efficient delivery and endo-lysosomal release of active proteins in living cells remain a challenge in protein-based theranostics. We report a novel protein delivery platform using protein-encapsulating biomineralized metal–organic framework (MOF) nanoparticles (NPs). This platform introduces an adapted biomimetic mineralization method for facile synthesis of MOF NPs with high protein encapsulation efficiency and a new polymer coating strategy to confer the NPs with long-term stability. In vitro results show that protein-encapsulating MOF NPs have the advantages of preserving protein activity for months and protecting proteins from enzyme-mediated degradation. Live cell studies reveal that MOF NPs enable rapid cellular uptake, efficient release and escape of proteins from endo-lysosomes, and preservation of protein activity in living cells. Moreover, the developed platform is demonstrated to enable easy encapsulation of multiple proteins in single MOF NPs for efficient protein co-delivery. To our knowledge, it is the first time that protein-encapsulating MOF NPs have been developed as a generally applicable strategy for intracellular delivery of native active proteins. The developed protein-encapsulating biomineralized MOF NPs can provide a valuable platform for protein-based theranostic applications. Efficient delivery and endo-lysosomal release of active proteins in living cells remain a challenge in protein-based theranostics. We report a novel protein delivery platform using protein-encapsulating biomineralized metal-organic framework (MOF) nanoparticles (NPs). This platform introduces an adapted biomimetic mineralization method for facile synthesis of MOF NPs with high protein encapsulation efficiency and a new polymer coating strategy to confer the NPs with long-term stability. In vitro results show that protein-encapsulating MOF NPs have the advantages of preserving protein activity for months and protecting proteins from enzyme-mediated degradation. Live cell studies reveal that MOF NPs enable rapid cellular uptake, efficient release and escape of proteins from endo-lysosomes, and preservation of protein activity in living cells. Moreover, the developed platform is demonstrated to enable easy encapsulation of multiple proteins in single MOF NPs for efficient protein co-delivery. To our knowledge, it is the first time that protein-encapsulating MOF NPs have been developed as a generally applicable strategy for intracellular delivery of native active proteins. The developed protein-encapsulating biomineralized MOF NPs can provide a valuable platform for protein-based theranostic applications.Efficient delivery and endo-lysosomal release of active proteins in living cells remain a challenge in protein-based theranostics. We report a novel protein delivery platform using protein-encapsulating biomineralized metal-organic framework (MOF) nanoparticles (NPs). This platform introduces an adapted biomimetic mineralization method for facile synthesis of MOF NPs with high protein encapsulation efficiency and a new polymer coating strategy to confer the NPs with long-term stability. In vitro results show that protein-encapsulating MOF NPs have the advantages of preserving protein activity for months and protecting proteins from enzyme-mediated degradation. Live cell studies reveal that MOF NPs enable rapid cellular uptake, efficient release and escape of proteins from endo-lysosomes, and preservation of protein activity in living cells. Moreover, the developed platform is demonstrated to enable easy encapsulation of multiple proteins in single MOF NPs for efficient protein co-delivery. To our knowledge, it is the first time that protein-encapsulating MOF NPs have been developed as a generally applicable strategy for intracellular delivery of native active proteins. The developed protein-encapsulating biomineralized MOF NPs can provide a valuable platform for protein-based theranostic applications. |
| Author | Yi, Jin-Tao Chu, Xia Chen, Ting-Ting Zhao, Yan-Yan |
| AuthorAffiliation | State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering |
| AuthorAffiliation_xml | – name: State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering |
| Author_xml | – sequence: 1 givenname: Ting-Ting surname: Chen fullname: Chen, Ting-Ting – sequence: 2 givenname: Jin-Tao surname: Yi fullname: Yi, Jin-Tao – sequence: 3 givenname: Yan-Yan surname: Zhao fullname: Zhao, Yan-Yan – sequence: 4 givenname: Xia orcidid: 0000-0002-4120-6131 surname: Chu fullname: Chu, Xia email: xiachu@hnu.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30008215$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1021/jacs.5b11720 10.1021/jacs.7b01794 10.1038/87548 10.1016/j.jcis.2014.03.014 10.1073/pnas.0602439103 10.1002/anie.201508288 10.1021/jacs.5b13458 10.1021/acs.chemrev.7b00091 10.1039/c0cs00227e 10.1038/nmeth.2998 10.1021/cr200304e 10.1002/anie.201004937 10.1039/c0cc05002d 10.1002/anie.201407234 10.1021/jacs.7b01214 10.1021/jacs.7b11754 10.1002/(SICI)1097-0290(20000120)67:2<217::AID-BIT11>3.0.CO;2-Q 10.1016/j.cell.2015.03.028 10.1021/ja4098862 10.1002/anie.201708005 10.1038/nrd2399 10.1002/anie.201506030 10.1021/bc500320j 10.1021/jacs.5b09711 10.1002/anie.201311245 10.1021/cr200274s 10.1038/nbt.3081 10.1038/s41598-017-12786-6 10.1021/nl5026419 10.1038/nnano.2009.341 10.1021/jacs.7b01229 10.1021/jacs.7b07895 10.1038/ncomms8240 10.1021/cb1001153 10.1021/acsami.6b05538 10.1039/C5CC05136C 10.1084/jem.182.5.1545 10.1021/ja907887z 10.1021/cr200190s 10.1021/jacs.6b06663 10.1021/ja513058h 10.1038/nrm3738 10.1021/nn406590q 10.1016/S0022-1759(02)00069-8 10.1016/j.biomaterials.2017.01.017 |
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| Title | Biomineralized Metal–Organic Framework Nanoparticles Enable Intracellular Delivery and Endo-Lysosomal Release of Native Active Proteins |
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