Association of Progressive Cerebellar Atrophy With Long-term Outcome in Patients With Anti-N-Methyl-d-Aspartate Receptor Encephalitis

• Published in: JAMA neurology Vol. 73; no. 6; p. 706
• Main Authors: Iizuka, Takahiro, Kaneko, Juntaro, Tominaga, Naomi, Someko, Hidehiro, Nakamura, Masaaki, Ishima, Daisuke, Kitamura, Eiji, Masuda, Ray, Oguni, Eiichi, Yanagisawa, Toshiyuki, Kanazawa, Naomi, Dalmau, Josep, Nishiyama, Kazutoshi
• Format: Journal Article
• Language: English
• Published: United States 01.06.2016
• Subjects: Adolescent; Adult; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - complications; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnostic imaging; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - metabolism; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - therapy; Antibodies - blood; Antibodies - cerebrospinal fluid; Atrophy - diagnostic imaging; Atrophy - etiology; Cerebellum - diagnostic imaging; Cerebellum - pathology; Female; Humans; Image Processing, Computer-Assisted; Immunotherapy - methods; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neurologic Examination; Receptors, N-Methyl-D-Aspartate - immunology; Retrospective Studies; Young Adult

Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an immune-mediated disorder that occurs with IgG antibodies against the GluN1 subunit of NMDAR. Some patients develop reversible diffuse cerebral atrophy (DCA), but the long-term clinical significance of progressive brain and cerebellar atro...