Identification and evolution of novel cfr -carrying plasmids in XDR Klebsiella pneumoniae strains from a chicken farm

• Published in: Microbiology spectrum Vol. 13; no. 5; p. e0262824
• Main Authors: Feng, Yiming, Li, Tiantian, Zhao, Shiyun, Zheng, Mengxiang, Shen, Jiaxing, Wu, Xiaoying, Li, Xuexue, Zhai, Yajun, Yuan, Li, Liu, Jianhua, Hu, Gongzheng, Pan, Yushan, He, Dandan
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 06.05.2025
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Antimicrobial Chemotherapy; Bacterial Proteins - genetics; cfr; Chickens - microbiology; Drug Resistance, Multiple, Bacterial - genetics; Evolution, Molecular; Farms; Fusion plasmid; Klebsiella Infections - microbiology; Klebsiella Infections - veterinary; Klebsiella pneumoniae; Klebsiella pneumoniae - classification; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - genetics; Klebsiella pneumoniae - isolation & purification; Microbial Sensitivity Tests; Plasmids - genetics; Poultry Diseases - microbiology; Research Article; TnAs1; Whole Genome Sequencing; Klebsiella pneumoniae; cfr; Fusion plasmid; TnAs1

This study highlights the alarming role of K. pneumoniae in the spread of antibiotic resistance within agricultural environments. Two strains isolated from a chicken farm were found to carry the cfr gene, conferring resistance to multiple critical antibiotics, including tigecycline and colistin. Des...