Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals

• Published in: Chemical research in toxicology Vol. 37; no. 3; pp. 465 - 475
• Main Authors: Thienpont, Anouck, Cho, Eunnara, Williams, Andrew, Meier, Matthew J., Yauk, Carole L., Rogiers, Vera, Vanhaecke, Tamara, Mertens, Birgit
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 18.03.2024

To modernize genotoxicity assessment and reduce reliance on experimental animals, new approach methodologies (NAMs) that provide human-relevant dose–response data are needed. Two transcriptomic biomarkers, GENOMARK and TGx-DDI, have shown a high classification accuracy for genotoxicity. As these bio...