Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies

• Published in: Annual review of chemical and biomolecular engineering Vol. 2; p. 281
• Main Authors: Chauhan, Vikash P, Stylianopoulos, Triantafyllos, Boucher, Yves, Jain, Rakesh K
• Format: Journal Article
• Language: English
• Published: United States 15.07.2011
• Subjects: Animals; Biological Transport - physiology; Capillary Permeability; Drug Delivery Systems - methods; Extracellular Space - metabolism; Humans; Nanostructures; Neoplasms - drug therapy; Neoplasms - pathology; Neoplasms - physiopathology; Tumor Microenvironment

Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport into tumor interstitium from the vascular compartment, and hindered transpo...