Electrodeposited Assembly of Additive-Free Silk Fibroin Coating from Pre-Assembled Nanospheres for Drug Delivery

• Published in: ACS applied materials & interfaces Vol. 12; no. 10; pp. 12018 - 12029
• Main Authors: Cheng, Xian, Deng, Dongmei, Chen, Lili, Jansen, John A, Leeuwenburgh, Sander G. C, Yang, Fang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.03.2020
• Subjects: additives; adhesion; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; antibiotics; Coated Materials, Biocompatible - chemistry; coatings; cytotoxicity; Drug Delivery Systems - methods; drugs; electroplating; Electroplating - methods; electrostatic interactions; fibroins; Fibroins - chemistry; hydrophobic bonding; hydrophobicity; medical equipment; Mice; nanospheres; Nanospheres - chemistry; neutralization; NIH 3T3 Cells; oxidation; polymers; prostheses; Staphylococcus aureus - drug effects; therapeutics; Vancomycin - chemistry; Vancomycin - pharmacokinetics; Vancomycin - pharmacology; coating; drug delivery; electrodeposition; pre-assembly; silk fibroin

Electrophoretically deposited (EPD) polymer-based coatings have been extensively reported as reservoirs in medical devices for delivery of therapeutic agents, but control over drug release remains a challenge. Here, a simple but uncommon assembly strategy for EPD polymer coatings was proposed to imp...