Absolute quantification of viral proteins from pseudotyped VSV-GP using UPLC-MRM

• Published in: Microbiology spectrum Vol. 12; no. 8; p. e0365123
• Main Authors: Basu, Rajeswari, Dambra, Richard, Jiang, Di, Schätzlein, Sophia A., Njiyang, Shu, Ashour, Joseph, Chiramel, Abhilash I., Vigil, Adam, Papov, Vladimir V.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 06.08.2024
• Subjects: absolute quantification; Genomics and Proteomics; GPC tracking; oncolytic virus; Research Article; GPC tracking; oncolytic virus; absolute quantification

The development of oncolytic viral therapy has gained considerable momentum in recent years. Vesicular stomatitis virus glycoprotein (VSV-GP) is a new biotherapeutic emerging in the oncolytic viral therapy platform. Novel analytical assays that can accurately and precisely quantify the viral protein...