Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS - Schenck Eidam, Hilary; Russell, John; Raha, Kaushik; DeMartino, Michael; Qin, Donghui; Guan, Huiping Amy; Zhang, Zhiliu; Zhen, Gong; Yu, Haiyu; Wu, Chengde; Pan, Yan; Joberty, Gerard; et al. (ACS medicinal chemistry letters, 2018)
Keywords: Chemistry, Medicinal; Letter; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; genotoxicity; RET kinase; IBS; AMES; gut restricted; DISORDERS; MECHANISMS; HIRSCHSPRUNGS-DISEASE; FAMILY; GDNF; GROWTH; NEURONS; EXPRESSION; IRRITABLE-BOWEL-SYNDROME; HYPERSENSITIVITY