Novel Sustainable-by-Design HDAC Inhibitors for the Treatment of Alzheimer’s Disease
Alzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhib...
Saved in:
Published in | ACS medicinal chemistry letters Vol. 10; no. 4; pp. 671 - 676 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
11.04.2019
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Alzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhibitor vorinostat (1), we develop the first HDAC inhibitors derived from cashew nut shell liquid (CNSL), an inexpensive agro-food waste material. CNSL derivatives 8 and 9 display a HDAC inhibitory profile similar to 1, together with a more promising safety for 9 compared to 1. Moreover, both compounds and particularly 9 were able to effectively modulate glial cell-induced inflammation and to revert the pro-inflammatory phenotype. All these results demonstrate that the use of inexpensive food waste materials could be successfully applied for the development of accessible and sustainable drug candidates for the treatment of AD. |
---|---|
AbstractList | Alzheimer's disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhibitor vorinostat (1), we develop the first HDAC inhibitors derived from cashew nut shell liquid (CNSL), an inexpensive agro-food waste material. CNSL derivatives 8 and 9 display a HDAC inhibitory profile similar to 1, together with a more promising safety for 9 compared to 1. Moreover, both compounds and particularly 9 were able to effectively modulate glial cell-induced inflammation and to revert the pro-inflammatory phenotype. All these results demonstrate that the use of inexpensive food waste materials could be successfully applied for the development of accessible and sustainable drug candidates for the treatment of AD. Alzheimer's disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhibitor vorinostat ( ), we develop the first HDAC inhibitors derived from cashew nut shell liquid (CNSL), an inexpensive agro-food waste material. CNSL derivatives and display a HDAC inhibitory profile similar to , together with a more promising safety for compared to . Moreover, both compounds and particularly were able to effectively modulate glial cell-induced inflammation and to revert the pro-inflammatory phenotype. All these results demonstrate that the use of inexpensive food waste materials could be successfully applied for the development of accessible and sustainable drug candidates for the treatment of AD. Alzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhibitor vorinostat ( 1 ), we develop the first HDAC inhibitors derived from cashew nut shell liquid (CNSL), an inexpensive agro-food waste material. CNSL derivatives 8 and 9 display a HDAC inhibitory profile similar to 1 , together with a more promising safety for 9 compared to 1 . Moreover, both compounds and particularly 9 were able to effectively modulate glial cell-induced inflammation and to revert the pro-inflammatory phenotype. All these results demonstrate that the use of inexpensive food waste materials could be successfully applied for the development of accessible and sustainable drug candidates for the treatment of AD. |
Author | Rossi, Michele Jung, Manfred de Oliveira Miranda, Camila da Costa Nunes, Jéssica Larissa Vistoli, Giulio Gervasoni, Silvia Simões Heyn Roth Cardoso, Gabriella Petralla, Sabrina Soukup, Ondrej Massenzio, Francesca Monti, Barbara Bolognesi, Maria Laura Soares Romeiro, Luiz Antonio Senger, Johanna Kobrlova, Tereza Gandini, Annachiara de Oliveira, Andressa Souza |
AuthorAffiliation | University of Milan Department of Pharmaceutical Science Alma Mater Studiorum - University of Bologna University of Brasília Department of Neuroscience, Laboratory of Prion Biology LADETER University of Freiburg Department of Pharmacy and Biotechnology Institute of Pharmaceutical Sciences Department of Pharmacy, Health Sciences Faculty Biomedical Research Center |
AuthorAffiliation_xml | – name: Biomedical Research Center – name: Department of Pharmaceutical Science – name: LADETER – name: University of Milan – name: University of Brasília – name: Department of Neuroscience, Laboratory of Prion Biology – name: Department of Pharmacy, Health Sciences Faculty – name: Alma Mater Studiorum - University of Bologna – name: University of Freiburg – name: Institute of Pharmaceutical Sciences – name: Department of Pharmacy and Biotechnology |
Author_xml | – sequence: 1 givenname: Luiz Antonio surname: Soares Romeiro fullname: Soares Romeiro, Luiz Antonio email: luizromeiro@unb.br organization: LADETER – sequence: 2 givenname: Jéssica Larissa surname: da Costa Nunes fullname: da Costa Nunes, Jéssica Larissa organization: University of Brasília – sequence: 3 givenname: Camila surname: de Oliveira Miranda fullname: de Oliveira Miranda, Camila organization: University of Brasília – sequence: 4 givenname: Gabriella surname: Simões Heyn Roth Cardoso fullname: Simões Heyn Roth Cardoso, Gabriella organization: University of Brasília – sequence: 5 givenname: Andressa Souza surname: de Oliveira fullname: de Oliveira, Andressa Souza organization: University of Brasília – sequence: 6 givenname: Annachiara orcidid: 0000-0002-2888-9636 surname: Gandini fullname: Gandini, Annachiara organization: Department of Neuroscience, Laboratory of Prion Biology – sequence: 7 givenname: Tereza surname: Kobrlova fullname: Kobrlova, Tereza organization: Biomedical Research Center – sequence: 8 givenname: Ondrej surname: Soukup fullname: Soukup, Ondrej organization: Biomedical Research Center – sequence: 9 givenname: Michele surname: Rossi fullname: Rossi, Michele organization: Alma Mater Studiorum - University of Bologna – sequence: 10 givenname: Johanna surname: Senger fullname: Senger, Johanna organization: University of Freiburg – sequence: 11 givenname: Manfred orcidid: 0000-0002-6361-7716 surname: Jung fullname: Jung, Manfred organization: University of Freiburg – sequence: 12 givenname: Silvia surname: Gervasoni fullname: Gervasoni, Silvia organization: University of Milan – sequence: 13 givenname: Giulio orcidid: 0000-0002-3939-5172 surname: Vistoli fullname: Vistoli, Giulio organization: University of Milan – sequence: 14 givenname: Sabrina surname: Petralla fullname: Petralla, Sabrina organization: Alma Mater Studiorum - University of Bologna – sequence: 15 givenname: Francesca surname: Massenzio fullname: Massenzio, Francesca organization: Alma Mater Studiorum - University of Bologna – sequence: 16 givenname: Barbara surname: Monti fullname: Monti, Barbara organization: Alma Mater Studiorum - University of Bologna – sequence: 17 givenname: Maria Laura orcidid: 0000-0002-1289-5361 surname: Bolognesi fullname: Bolognesi, Maria Laura email: marialaura.bolognesi@unibo.it organization: Alma Mater Studiorum - University of Bologna |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30996816$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkc1q3DAUhUVIyV_zCsHLQnEqybZkbQKDp2kCoV106FZInqtYwZZSSU5JV32NvF6fpAozHZJVu9IFfefcwz3HaN95BwidEXxOMCUfVB8nWPcDTCOkdC40xpiTPXRERN2WTcub_RfzITqO8Q5jJjjHB-iwwkKwlrAj9O2zf4Cx-DrHpKxTeoRSP5ZLiPbWFVfLRVdcu8Fqm3yIhfGhSAMUqwAqTeBS4U2xGH8OYCcIv389xWJpI6gIb9Ebo8YIp9v3BK0uP666q_Lmy6frbnFTqrrhqeTrSjBWc40r3TRARWV6QUilMKYCFG244kpVpDbrtjU165taaVqDYAZAs-oEXWxs72f9fI4cKahR3gc7qfAovbLy9Y-zg7z1D5LVjLWUZIN3W4Pgv88Qk5xs7GEclQM_R0lpTkObiouMsg3aBx9jALNbQ7B87kS-7kRuO8nCs5chd7K_JWSg3QA_QHsTewuuhx2WTep8Ipaby5PobFLJetf52aUsff__0kzTDZ2Tyjs_B5e7-Vf8P03-wo8 |
CitedBy_id | crossref_primary_10_1080_17460441_2021_1877656 crossref_primary_10_2174_1568026623666230126112628 crossref_primary_10_1016_j_semcdb_2022_11_001 crossref_primary_10_1002_med_21701 crossref_primary_10_3390_cells12111464 crossref_primary_10_3390_futurepharmacol4020020 crossref_primary_10_3390_ph15010080 crossref_primary_10_1021_acs_jmedchem_1c00048 crossref_primary_10_1039_D1MD00046B crossref_primary_10_1016_j_cesys_2023_100132 crossref_primary_10_1093_mmy_myad073 crossref_primary_10_3389_fbioe_2021_629832 crossref_primary_10_3390_molecules26185441 crossref_primary_10_2174_1389557522666220217103441 crossref_primary_10_1021_acsinfecdis_3c00076 crossref_primary_10_1016_j_ejps_2019_105109 crossref_primary_10_1016_j_bioorg_2020_103721 crossref_primary_10_3390_biom11020306 |
Cites_doi | 10.1021/acs.jmedchem.7b00115 10.1074/jbc.M301580200 10.1111/jnc.14309 10.1016/j.ejmech.2011.11.001 10.1021/acschemneuro.8b00242 10.1074/jbc.M114.622209 10.1073/pnas.1501441112 10.1177/0891988710383571 10.1111/j.1365-2125.2012.04443.x 10.1038/nrn.2017.46 10.1186/s40035-017-0089-1 10.1186/alzrt269 10.1038/npp.2009.197 10.1016/j.pneurobio.2010.01.002 10.1016/j.ejmech.2015.12.024 10.1016/j.bmcl.2008.04.017 10.1016/S0140-6736(17)31757-9 10.1126/sciadv.1600584 10.1016/j.trci.2018.03.009 10.1186/1750-1326-8-7 10.1021/cn500021p 10.1186/1742-2094-3-27 10.1016/j.bmc.2010.06.089 10.20453/rnp.v80i2.3091 10.1021/ja102758v 10.1002/cmdc.201800790 10.1007/s41061-017-0177-9 10.3389/fnagi.2017.00175 10.1016/j.ymeth.2005.03.003 10.1007/978-3-319-47455-7_2 |
ContentType | Journal Article |
Copyright | Copyright © 2019 American Chemical Society 2019 American Chemical Society |
Copyright_xml | – notice: Copyright © 2019 American Chemical Society 2019 American Chemical Society |
DBID | 1KM AAWJD BLEPL DTL NPM AAYXX CITATION 7X8 5PM |
DOI | 10.1021/acsmedchemlett.9b00071 |
DatabaseName | Index Chemicus Web of Science - Science Citation Index Expanded - 2019 Web of Science Core Collection Science Citation Index Expanded PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | Web of Science PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | Web of Science PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 1KM name: Index Chemicus url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC sourceTypes: Enrichment Source Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1948-5875 |
EndPage | 676 |
ExternalDocumentID | 10_1021_acsmedchemlett_9b00071 30996816 000464767700049 b02115269 |
Genre | Journal Article |
GrantInformation_xml | – fundername: University of Brasilia (CNPq) grantid: 401864/2013-8 – fundername: University of Bologna (Grant RFO 2016) – fundername: program "Ciencia sem Fronteiras", Brazil grantid: 401864/2013-8 – fundername: project MH CZ-DRO (UHHK) grantid: 00179906 – fundername: Deutsche Forschungsgemeinschaft (DFG); German Research Foundation (DFG) grantid: Ju295/13-1 |
GroupedDBID | - 53G 55A 7~N AABXI ABMVS ABUCX ACGFS ACS ADACO ADBBV AEESW AENEX AFEFF ALMA_UNASSIGNED_HOLDINGS AQSVZ BAWUL DIK EBS ED ED~ EJD F5P GNL GX1 HYE IH9 JG JG~ OK1 P2P RNS ROL RPM UI2 VF5 VG9 W1F XKZ --- 1KM 5VS ABJNI ABQRX ACGFO ADHLV AHGAQ AOIJS BAANH BLEPL CUPRZ DTL GGK GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED NPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-a457t-7d396647b03b55e293fc9113a0029ea257a7aa314fd88f46c54ab24e96feeb63 |
IEDL.DBID | RPM |
ISICitedReferencesCount | 23 |
ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000464767700049 |
ISSN | 1948-5875 |
IngestDate | Tue Sep 17 21:25:48 EDT 2024 Fri Aug 16 22:57:18 EDT 2024 Fri Aug 23 03:26:09 EDT 2024 Sat Sep 28 08:29:02 EDT 2024 Fri Oct 11 20:19:05 EDT 2024 Tue Sep 17 23:13:29 EDT 2024 Thu Aug 27 13:44:03 EDT 2020 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | immunomodulation Neurodegenerative drug discovery sustainable drugs food waste SMALL-MOLECULE MODULATORS HISTONE |
Language | English |
LinkModel | DirectLink |
LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
MergedId | FETCHMERGED-LOGICAL-a457t-7d396647b03b55e293fc9113a0029ea257a7aa314fd88f46c54ab24e96feeb63 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-1289-5361 0000-0002-2888-9636 0000-0002-3939-5172 0000-0002-6361-7716 0000-0002-5189-7546 0000-0002-5731-3396 0000-0003-4009-5676 0000-0003-0330-482X 0000-0002-4445-0287 |
OpenAccessLink | https://europepmc.org/articles/pmc6466821?pdf=render |
PMID | 30996816 |
PQID | 2211325379 |
PQPubID | 23479 |
PageCount | 6 |
ParticipantIDs | webofscience_primary_000464767700049CitationCount pubmedcentral_primary_oai_pubmedcentral_nih_gov_6466821 acs_journals_10_1021_acsmedchemlett_9b00071 pubmed_primary_30996816 crossref_primary_10_1021_acsmedchemlett_9b00071 webofscience_primary_000464767700049 proquest_miscellaneous_2211325379 |
ProviderPackageCode | JG~ 55A AABXI GNL VF5 XKZ 7~N VG9 W1F ACS AEESW AFEFF ABMVS ABUCX IH9 AQSVZ ED~ UI2 |
PublicationCentury | 2000 |
PublicationDate | 2019-04-11 |
PublicationDateYYYYMMDD | 2019-04-11 |
PublicationDate_xml | – month: 04 year: 2019 text: 2019-04-11 day: 11 |
PublicationDecade | 2010 |
PublicationPlace | WASHINGTON |
PublicationPlace_xml | – name: WASHINGTON – name: United States |
PublicationTitle | ACS medicinal chemistry letters |
PublicationTitleAbbrev | ACS MED CHEM LETT |
PublicationTitleAlternate | ACS Med. Chem. Lett |
PublicationYear | 2019 |
Publisher | American Chemical Society Amer Chemical Soc |
Publisher_xml | – name: American Chemical Society – name: Amer Chemical Soc |
References | Cerone, M (WOS:000462153500002) 2019; 14 Seo, YJ (WOS:000339226100015) 2014; 5 Butler, KV (WOS:000280692200044) 2010; 132 Wang, GH (WOS:000350224900065) 2015; 112 Kilgore, M (WOS:000274424900004) 2010; 35 Caraci, F (WOS:000316326200031) 2013; 75 Hwang, JY (WOS:000401517300008) 2017; 18 Hori, Y (WOS:000356177300030) 2015; 290 Chouliaras, L (WOS:000276770000005) 2010; 90 Mubofu, EB (WOS:000426498500001) 2018; 376 Heltweg, B (WOS:000231794600002) 2005; 36 Prince, M (WOS:000418101000001) 2017; 390 Ghizzoni, M (WOS:000301169800036) 2012; 47 Lomonaco, D. (000464767700049.18) 2017 Marciani, Dante J (SCIELO:S0034-85972017000200004) 2017; 80 Pena-Altamira, E (WOS:000403761200002) 2017; 9 Lemes, LFN (WOS:000369191800060) 2016; 108 Ghizzoni, M (WOS:000280664100005) 2010; 18 Yang, SS (WOS:000405110800001) 2017; 6 Uliassi, E (WOS:000456351300034) 2019; 10 Thomas, EA (WOS:000430917900001) 2018; 145 Simoes-Pires, C (WOS:000317047900001) 2013; 8 Balasubramanyam, K (WOS:000182932200055) 2003; 278 Colton, CA (WOS:000246971200001) 2006; 3 Bekris, LM (WOS:000283714000002) 2010; 23 Bourguet, E (WOS:000427331500001) 2018; 61 Cummings, Jeffrey (MEDLINE:29955663) 2018; 4 Pal, S (WOS:000381805300034) 2016; 2 Sbardella, G (WOS:000255444300005) 2008; 18 Cummings, JL (WOS:000343200200001) 2014; 6 ref9/cit9 ref6/cit6 ref3/cit3 ref27/cit27 ref18/cit18 ref11/cit11 ref25/cit25 ref16/cit16 ref29/cit29 ref32/cit32 ref23/cit23 ref14/cit14 ref8/cit8 ref5/cit5 ref31/cit31 ref2/cit2 Lomonaco D. (ref19/cit19) 2017 ref28/cit28 ref20/cit20 ref17/cit17 ref10/cit10 ref26/cit26 ref21/cit21 ref12/cit12 ref15/cit15 ref22/cit22 ref13/cit13 ref4/cit4 ref30/cit30 ref1/cit1 ref24/cit24 ref7/cit7 |
References_xml | – volume: 61 start-page: 1745 year: 2018 ident: WOS:000427331500001 article-title: Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD) publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/acs.jmedchem.7b00115 contributor: fullname: Bourguet, E – volume: 278 start-page: 19134 year: 2003 ident: WOS:000182932200055 article-title: Small molecule modulators of histone acetyltransferase p300 publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY doi: 10.1074/jbc.M301580200 contributor: fullname: Balasubramanyam, K – volume: 145 start-page: 96 year: 2018 ident: WOS:000430917900001 article-title: Complex neuroprotective and neurotoxic effects of histone deacetylases publication-title: JOURNAL OF NEUROCHEMISTRY doi: 10.1111/jnc.14309 contributor: fullname: Thomas, EA – volume: 47 start-page: 337 year: 2012 ident: WOS:000301169800036 article-title: 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2011.11.001 contributor: fullname: Ghizzoni, M – volume: 10 start-page: 279 year: 2019 ident: WOS:000456351300034 article-title: A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential publication-title: ACS CHEMICAL NEUROSCIENCE doi: 10.1021/acschemneuro.8b00242 contributor: fullname: Uliassi, E – volume: 290 start-page: 15163 year: 2015 ident: WOS:000356177300030 article-title: Role of Apolipoprotein E in beta-Amyloidogenesis ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF A beta IN VITRO AND BRAIN A beta DEPOSITION IN VIVO publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY doi: 10.1074/jbc.M114.622209 contributor: fullname: Hori, Y – volume: 112 start-page: 2853 year: 2015 ident: WOS:000350224900065 article-title: HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3 beta/PTEN/Akt axis publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA doi: 10.1073/pnas.1501441112 contributor: fullname: Wang, GH – volume: 23 start-page: 213 year: 2010 ident: WOS:000283714000002 article-title: Genetics of Alzheimer Disease publication-title: JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY doi: 10.1177/0891988710383571 contributor: fullname: Bekris, LM – volume: 75 start-page: 1154 year: 2013 ident: WOS:000316326200031 article-title: Epigenetic drugs for Alzheimer's disease: hopes and challenges publication-title: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY doi: 10.1111/j.1365-2125.2012.04443.x contributor: fullname: Caraci, F – volume: 18 start-page: 347 year: 2017 ident: WOS:000401517300008 article-title: The emerging field of epigenetics in neurodegeneration and neuroprotection publication-title: NATURE REVIEWS NEUROSCIENCE doi: 10.1038/nrn.2017.46 contributor: fullname: Hwang, JY – volume: 6 start-page: ARTN 19 year: 2017 ident: WOS:000405110800001 article-title: The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease publication-title: TRANSLATIONAL NEURODEGENERATION doi: 10.1186/s40035-017-0089-1 contributor: fullname: Yang, SS – volume: 6 start-page: ARTN 37 year: 2014 ident: WOS:000343200200001 article-title: Alzheimer's disease drug-development pipeline: few candidates, frequent failures publication-title: ALZHEIMERS RESEARCH & THERAPY doi: 10.1186/alzrt269 contributor: fullname: Cummings, JL – volume: 35 start-page: 870 year: 2010 ident: WOS:000274424900004 article-title: Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease publication-title: NEUROPSYCHOPHARMACOLOGY doi: 10.1038/npp.2009.197 contributor: fullname: Kilgore, M – volume: 90 start-page: 498 year: 2010 ident: WOS:000276770000005 article-title: Epigenetic regulation in the pathophysiology of Alzheimer's disease publication-title: PROGRESS IN NEUROBIOLOGY doi: 10.1016/j.pneurobio.2010.01.002 contributor: fullname: Chouliaras, L – volume: 108 start-page: 687 year: 2016 ident: WOS:000369191800060 article-title: Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2015.12.024 contributor: fullname: Lemes, LFN – volume: 18 start-page: 2788 year: 2008 ident: WOS:000255444300005 article-title: Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS doi: 10.1016/j.bmcl.2008.04.017 contributor: fullname: Sbardella, G – start-page: 19 year: 2017 ident: 000464767700049.18 article-title: Cashew Nutshell Liquid (CNSL): From an Agro-industrial Waste to a Sustainable Alternative to Petrochemical Resources publication-title: Cashew Nut Shell Liquid contributor: fullname: Lomonaco, D. – volume: 390 start-page: E51 year: 2017 ident: WOS:000418101000001 article-title: Progress on dementia-leaving no one behind publication-title: LANCET doi: 10.1016/S0140-6736(17)31757-9 contributor: fullname: Prince, M – volume: 2 start-page: ARTN e1600584 year: 2016 ident: WOS:000381805300034 article-title: Epigenetics and aging publication-title: SCIENCE ADVANCES doi: 10.1126/sciadv.1600584 contributor: fullname: Pal, S – volume: 4 start-page: 195 year: 2018 ident: MEDLINE:29955663 article-title: Alzheimer's disease drug development pipeline: 2018. publication-title: Alzheimer's & dementia (New York, N. Y.) doi: 10.1016/j.trci.2018.03.009 contributor: fullname: Cummings, Jeffrey – volume: 8 start-page: ARTN 7 year: 2013 ident: WOS:000317047900001 article-title: HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs? publication-title: MOLECULAR NEURODEGENERATION doi: 10.1186/1750-1326-8-7 contributor: fullname: Simoes-Pires, C – volume: 5 start-page: 588 year: 2014 ident: WOS:000339226100015 article-title: Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors publication-title: ACS CHEMICAL NEUROSCIENCE doi: 10.1021/cn500021p contributor: fullname: Seo, YJ – volume: 3 start-page: ARTN 27 year: 2006 ident: WOS:000246971200001 article-title: Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD publication-title: JOURNAL OF NEUROINFLAMMATION doi: 10.1186/1742-2094-3-27 contributor: fullname: Colton, CA – volume: 18 start-page: 5826 year: 2010 ident: WOS:000280664100005 article-title: Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative publication-title: BIOORGANIC & MEDICINAL CHEMISTRY doi: 10.1016/j.bmc.2010.06.089 contributor: fullname: Ghizzoni, M – volume: 80 start-page: 105 year: 2017 ident: SCIELO:S0034-85972017000200004 article-title: Facing Alzheimers disease in the developing countries publication-title: Revista de Neuro-Psiquiatra doi: 10.20453/rnp.v80i2.3091 contributor: fullname: Marciani, Dante J – volume: 132 start-page: 10842 year: 2010 ident: WOS:000280692200044 article-title: Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja102758v contributor: fullname: Butler, KV – volume: 14 start-page: 621 year: 2019 ident: WOS:000462153500002 article-title: Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei publication-title: CHEMMEDCHEM doi: 10.1002/cmdc.201800790 contributor: fullname: Cerone, M – volume: 376 start-page: ARTN 8 year: 2018 ident: WOS:000426498500001 article-title: Chemical Valorization of Cashew Nut Shell Waste publication-title: TOPICS IN CURRENT CHEMISTRY doi: 10.1007/s41061-017-0177-9 contributor: fullname: Mubofu, EB – volume: 9 start-page: ARTN 175 year: 2017 ident: WOS:000403761200002 article-title: Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer's Disease publication-title: FRONTIERS IN AGING NEUROSCIENCE doi: 10.3389/fnagi.2017.00175 contributor: fullname: Pena-Altamira, E – volume: 36 start-page: 332 year: 2005 ident: WOS:000231794600002 article-title: In vitro assays for the determination of histone deacetylase activity publication-title: METHODS doi: 10.1016/j.ymeth.2005.03.003 contributor: fullname: Heltweg, B – start-page: 19 volume-title: Cashew Nut Shell Liquid year: 2017 ident: ref19/cit19 doi: 10.1007/978-3-319-47455-7_2 contributor: fullname: Lomonaco D. – ident: ref13/cit13 doi: 10.1016/j.ejmech.2015.12.024 – ident: ref2/cit2 doi: 10.1016/j.trci.2018.03.009 – ident: ref32/cit32 doi: 10.1002/cmdc.201800790 – ident: ref14/cit14 doi: 10.1007/s41061-017-0177-9 – ident: ref25/cit25 doi: 10.1111/j.1365-2125.2012.04443.x – ident: ref28/cit28 doi: 10.1038/nrn.2017.46 – ident: ref10/cit10 doi: 10.1186/s40035-017-0089-1 – ident: ref5/cit5 doi: 10.1016/S0140-6736(17)31757-9 – ident: ref4/cit4 doi: 10.1186/alzrt269 – ident: ref18/cit18 doi: 10.1016/j.ejmech.2011.11.001 – ident: ref16/cit16 doi: 10.1016/j.bmcl.2008.04.017 – ident: ref26/cit26 doi: 10.1021/acschemneuro.8b00242 – ident: ref11/cit11 – ident: ref24/cit24 doi: 10.1021/cn500021p – ident: ref1/cit1 – ident: ref9/cit9 doi: 10.1126/sciadv.1600584 – ident: ref29/cit29 doi: 10.1186/1742-2094-3-27 – ident: ref31/cit31 doi: 10.1111/jnc.14309 – ident: ref21/cit21 doi: 10.1021/acs.jmedchem.7b00115 – ident: ref27/cit27 doi: 10.1073/pnas.1501441112 – ident: ref17/cit17 doi: 10.1016/j.bmc.2010.06.089 – ident: ref15/cit15 doi: 10.1074/jbc.M301580200 – ident: ref8/cit8 doi: 10.1016/j.pneurobio.2010.01.002 – ident: ref20/cit20 doi: 10.1021/ja102758v – ident: ref22/cit22 doi: 10.1186/1750-1326-8-7 – ident: ref23/cit23 doi: 10.1016/j.ymeth.2005.03.003 – ident: ref3/cit3 doi: 10.20453/rnp.v80i2.3091 – ident: ref7/cit7 doi: 10.1074/jbc.M114.622209 – ident: ref30/cit30 doi: 10.3389/fnagi.2017.00175 – ident: ref6/cit6 doi: 10.1177/0891988710383571 – ident: ref12/cit12 doi: 10.1038/npp.2009.197 |
SSID | ssj0069770 |
Score | 2.3510172 |
Snippet | Alzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050.... Alzheimer's disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050.... Alzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050.... |
Source | Web of Science |
SourceID | pubmedcentral proquest crossref pubmed webofscience acs |
SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
StartPage | 671 |
SubjectTerms | Chemistry, Medicinal Letter Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology |
SummonAdditionalLinks | – databaseName: American Chemical Society (ACS) Journals dbid: ACS link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwEB2VcuHCNzR8yUhVLzTbxHbs5LjapVqQqIq6oN4i2-toV7RZ1GSRtif-Bn-PX8LYSXZZSkU5x3HkydjzRjPvGWA3sZjrOJVPXlAe8oxFYZqyOJSMZpMI419hHcH5w5EYfeLvT5PTLYiuqeDT-ECZyrUqTu05LqTuZU1YvAW3KQZHl271Byfd2SsQzXgKZMYdn0gmHSf42nlcUDLVZlC6gjT_3jD5R5DyAenwHnzsaD1NH8qX3qLWPXN5VeXxxmu9D3dbdEr6jTs9gC1bPoS940beerlPxmu2VrVP9sjxWvh6-Qg-H82_2TNysuZkhXoZDn2PCBkN-wPyrpzO9Mxd8EMQLBMEn2TcdbqTeUH6Z5dTOzu3Fz-__6jIsCkePYbx4dvxYBS29zaEiieyDuWEYRLFpY6YThKLgKIweKYy5UqAVuEhoaRSLObFJE0LLkzClabcZugYVgv2BLbLeWl3gBQIPotIGGGk4ZhbpZpaJoQ2XuaG0gDeoMnydttVua-o0zjftGPe2jGAg-4v518bLY9_vvG6c4Yct52rpajSzhdVTjFxZjRhMgvgaeMcqzkZom6RxiIAueE2qwFO0nvzSTmbemlvwYVIKX5393cHW73oub5cCvRyl9oFEN9k2KBVe3cqB_Wz_zLZc7iDCNGXz-L4BWzXFwv7ElFYrV_5jfcLNkowbQ priority: 102 providerName: American Chemical Society |
Title | Novel Sustainable-by-Design HDAC Inhibitors for the Treatment of Alzheimer’s Disease |
URI | http://dx.doi.org/10.1021/acsmedchemlett.9b00071 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000464767700049 https://www.ncbi.nlm.nih.gov/pubmed/30996816 https://search.proquest.com/docview/2211325379 https://pubmed.ncbi.nlm.nih.gov/PMC6466821 |
Volume | 10 |
WOS | 000464767700049 |
WOSCitedRecordID | wos000464767700049 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtNAEB41PaBeEP-4QLVIVS_Uib273rWPkUMJSK0iNaDcLK-zViwlTlW7SOHEa_B6PAmzazshgATi4otnrZVnZucbzcy3AKeBxlzHsHzynHKXR8xzw5D5rmQ0mnsY_3JtBpwvr8T4I_8wC2YHEHSzMLZpP1NFv1yu-mWxsL2VN6ts0PWJDSaXseBChNQf9KAnGetS9Ob4FQhovG4UGGXSrDKdjgu9wv9Q96Mmqh7BPYbYSITmnvMeyuyHpd-w5p9bJn8JUzYkXTyA-y2WJMNmzw_hQJeP4GzSkFFvzsl0N1tVnZMzMtnRVG8ew6er9We9JNe7CSpXbdyR7egg49EwJu_LRaEKcx0PQWhLECqSadeXTtY5GS6_LHSx0rffv36ryKgp9TyB6cXbaTx221sW3JQHsnblnGHKw6XymAoCjeE_z_AEZKkp2OkUXTqVacp8ns_DMOciC3iqKNcRqlErwZ7CYbku9XMgOULF3BOZyGTGMRMKFdVMCJVZUhpKHXiDfzppnaRKbP2b-sm-ipJWRQ4MOo0kNw3zxl9XvO4Ul6CTmMpHWur1XZVQTHMZDZiMHHjWKHL7zc4OHJB7Kt4KGALu_Tdol5aIu7VDB05_NobtQjuZy6VAgzSJmAP-v4jFLTe74SSoj_97Uy_gCLGdLXz5_ks4rG_v9CvET7U6wfwhvsbnu5l_Yn3nB3m5Hww |
link.rule.ids | 230,315,733,786,790,891,2782,27107,27955,27956,53825,53827,57091,57141 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB5BOcCFN8U8F6nqhTqN92kfo4QqhTaqVINys7zOWoloHVQ7SOmJv8Hf45cwu7YTUkA8rvbu2jue3fnGM_MtwI4w6OtYlk-eU-7ziHX9MGSBrxiNJl20f7mxBc7HIzl8z9-Oxbj5dWFrYfAlShypdEH8NbtAsI_XbMbi1JzjfKpOVFvH63BDKDR5FhP1T9stWCKocZWQEbdlRUq0pcG_HcfapqzctE0_Ac5f501esVXOLh3cgfFqRi4d5WNnUelOdnmF7PE_pnwXbjdYlfRq5boH10xxH3ZParLr5R6J17Vb5R7ZJSdrGuzlA_gwmn82Z-R0XaHl66U_cBkjZDjo9clhMZ3pmT3uhyB0JghFSdzmvZN5Tnpnl1MzOzcX3758LcmgDiU9hPjgTdwf-s0pDn7Khap8NWHoUnGlu0wLYRBe5BnusCy1AUGT4paRqjRlAc8nYZhzmQmeaspNhGpitGSPYKuYF-YxkByhaN6VmcxUxtHTCjU1TEqdOdIbSj14jSJLmkVYJi6-ToNkU45JI0cP9tuPnXyqmT3-2ONVqxMJLkIbWUkLM1-UCUU3mlHBVOTBdq0jqzEZYnAZBtIDtaE9qwaW4HvzTjGbOqJvyaUMKT5350c9W3V0lb9cSVR26-h5EPxNs37D_W45D6on_ySyl3BzGB8fJUeHo3dP4RZiRxdYC4JnsFVdLMxzxGeVfuHW4ndjHzjY |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6VIiEuvCnmuUhVL9RpvE9bnKKEKOURRWpAPSBZXmetRLROVTtI6Ym_wd_jlzC7thNSQDyutnftHc_sfKOZ-RZgVxiMdSzLJ88o93nE2n4YssBXjEaTNvq_zNgG53dDOXjPXx-L4y142fTC4EcUOFPhkvjWqs8mWc0wEBzgdVu1ODWnuKayFVUe8gpcFSrg1io73aNmG5YIbFw3ZMRta5ESTXvwb-ex_iktNv3TT6Dz17WTl_yV8039m_BxtSpXkvKptSh1K724RPj4n8u-BTdqzEo6lZLdhi2T34G9UUV6vdwn43UPV7FP9shoTYe9vAsfhvPP5oQcrTu1fL30e65yhAx6nS45zKczPbPH_hCE0AQhKRk39e9knpHOycXUzE7N-bcvXwvSq1JK92DcfzXuDvz6NAc_4UKVvpowDK240m2mhTAIM7IUd1qW2MSgSXDrSFSSsIBnkzDMuEwFTzTlJkJ1MVqy-7Cdz3PzAEiGkDRry1SmKuUYcYWaGialTh35DaUevECRxbUxFrHLs9Mg3pRjXMvRg4Pmh8dnFcPHH0c8b_QiRmO0GZYkN_NFEVMMpxkVTEUe7FR6spqTIRaXYSA9UBsatHrAEn1v3slnU0f4LbmUIcX37v6oa6uBrgOYK4kKbwM-D4K_eaxbc8Bb7oPy4T-J7BlcG_X68dvD4ZtHcB0hpMuvBcFj2C7PF-YJwrRSP3Xm-B0baDtS |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+Sustainable-by-Design+HDAC+Inhibitors+for+the+Treatment+of+Alzheimer%E2%80%99s+Disease&rft.jtitle=ACS+medicinal+chemistry+letters&rft.au=Soares+Romeiro%2C+Luiz+Antonio&rft.au=da+Costa+Nunes%2C+Je%CC%81ssica+Larissa&rft.au=de+Oliveira+Miranda%2C+Camila&rft.au=Simo%CC%83es+Heyn+Roth+Cardoso%2C+Gabriella&rft.date=2019-04-11&rft.pub=American+Chemical+Society&rft.issn=1948-5875&rft.eissn=1948-5875&rft.volume=10&rft.issue=4&rft.spage=671&rft.epage=676&rft_id=info:doi/10.1021%2Facsmedchemlett.9b00071&rft.externalDocID=b02115269 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1948-5875&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1948-5875&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1948-5875&client=summon |