Efficient Semisynthesis of (−)-Pseudoirroratin A from (−)-Flexicaulin A and Assessment of Their Antitumor Activities

• Published in: ACS medicinal chemistry letters Vol. 8; no. 3; pp. 372 - 376
• Main Authors: Guo, Lei, Tsang, Siu Wai, Zhang, Tong-Xin, Liu, Kang-Lun, Guan, Yi-Fu, Wang, Bo, Sun, Han-Dong, Zhang, Hong-Jie, Wong, Man Shing
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 09.03.2017; Amer Chemical Soc
• Subjects: Chemistry, Medicinal; Letter; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; apoptosis; (−)-Pseudoirroratin A; (−)-flexicaulin A; antitumor activity; ENT-KAURANE DITERPENOIDS; LEUKEMIC-CELLS; (-)-Pseudoirroratin A; DEATH; (-)-flexicaulin A; DIFFERENTIATION

Accumulating evidence indicates that natural ent-kaurane diterpenoids show great potential for medical treatment of different pathological conditions including cytotoxicity, antibacterial, and anti-inflammatory activity. Among a variety of diterpenoids tested, (−)-pseudoirroratin A displayed a promi...