Dysbiosis of gut microbiota in COVID-19 is associated with intestinal DNA phage dynamics of lysogenic and lytic infection

• Published in: Microbiology spectrum Vol. 13; no. 1; p. e0099824
• Main Authors: Ishizaka, Aya, Tamura, Azumi, Koga, Michiko, Mizutani, Taketoshi, Yamayoshi, Seiya, Iwatsuki-Horimoto, Kiyoko, Yasuhara, Atsuhiro, Yamamoto, Shinya, Nagai, Hiroyuki, Adachi, Eisuke, Suzuki, Yutaka, Kawaoka, Yoshihiro, Yotsuyanagi, Hiroshi
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 07.01.2025
• Subjects: Adult; Aged; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Bacteria - virology; bacteriophages; Bacteriophages - genetics; Bacteriophages - isolation & purification; Bacteriophages - physiology; Clinical Microbiology; COVID-19; COVID-19 - microbiology; COVID-19 - virology; DNA, Viral - genetics; Dysbiosis - microbiology; Dysbiosis - virology; Feces - microbiology; Feces - virology; Female; Gastrointestinal Microbiome; gut microbiome; Humans; Intestines - microbiology; Intestines - virology; Lysogeny; Male; Middle Aged; Research Article; SARS-CoV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - physiology; Virome; COVID-19; SARS-CoV-2; gut microbiome; bacteriophages

Bacteriophages infect and replicate with bacteria and archaea and are closely associated with intestinal bacteria. The symbiotic relationship between gut microbiota and bacteriophages is of interest, but it is challenging to study their dynamics in the human body over time. SARS-CoV-2 infection has...