Assessment of the Antileishmanial Potential of Cassia fistula Leaf Extract
Cassia fistula has a wide array of biologically active and therapeutically important class of compounds. Leishmania donovani important drug targets, sterol 24-c methyltransferase (LdSMT), trypanothione reductase (LdTR), pteridine reductase (LdPTR1), and nucleoside hydrolase (LdNH), were modelled, an...
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| Published in | ACS omega Vol. 6; no. 3; pp. 2318 - 2327 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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American Chemical Society
26.01.2021
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| Abstract | Cassia fistula has a wide array of biologically active and therapeutically important class of compounds. Leishmania donovani important drug targets, sterol 24-c methyltransferase (LdSMT), trypanothione reductase (LdTR), pteridine reductase (LdPTR1), and nucleoside hydrolase (LdNH), were modelled, and molecular docking was performed against the abundant phytochemicals of its leaf extract. Molecular docking results provided the significant prima facie evidence of the leaf extract to have antileishmanial potential. To confirm this, we performed in vitro antileishmanial and cytotoxicity assays. Methanolic extract of C. fistula leaves showed growth inhibition and proliferation of L. donovani promastigote with an IC50 value of 43.31 ± 4.202 μg/mL. It also inhibited the growth of intra-macrophagic amastigotes with an IC50 value of 80.76 ± 3.626 μg/mL. C. fistula extract was found cytotoxic at a very high concentration on human macrophages (CC50 = 626 ± 39 μg/mL). Annexin V/propidium iodide (PI) staining assay suggested partial apoptosis induction in parasites by C. fistula to exert its antileishmanial activity. Here, for the first time, we have shown the antileishmanial potential of C. fistula leaves. Overall, our results could open new insight for an affordable and natural antileishmanial with high efficacy and less toxicity. |
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| AbstractList | Cassia
fistula
has a wide array
of biologically active and therapeutically important class of compounds.
Leishmania donovani
important drug targets, sterol
24-c methyltransferase (
Ld
SMT), trypanothione reductase
(
Ld
TR), pteridine reductase (
Ld
PTR1),
and nucleoside hydrolase (
Ld
NH), were modelled, and
molecular docking was performed against the abundant phytochemicals
of its leaf extract. Molecular docking results provided the significant
prima facie evidence of the leaf extract to have antileishmanial potential.
To confirm this, we performed
in vitro
antileishmanial
and cytotoxicity assays. Methanolic extract of
C. fistula
leaves showed growth inhibition and proliferation of
L. donovani
promastigote with an IC
50
value
of 43.31 ± 4.202 μg/mL. It also inhibited the growth of
intra-macrophagic amastigotes with an IC
50
value of 80.76
± 3.626 μg/mL.
C. fistula
extract was found cytotoxic at a very high concentration on human
macrophages (CC
50
= 626 ± 39 μg/mL). Annexin
V/propidium iodide (PI) staining assay suggested partial apoptosis
induction in parasites by
C. fistula
to exert its antileishmanial activity. Here, for the first time,
we have shown the antileishmanial potential of
C. fistula
leaves. Overall, our results could open new insight for an affordable
and natural antileishmanial with high efficacy and less toxicity. has a wide array of biologically active and therapeutically important class of compounds. important drug targets, sterol 24-c methyltransferase ( SMT), trypanothione reductase ( TR), pteridine reductase ( PTR1), and nucleoside hydrolase ( NH), were modelled, and molecular docking was performed against the abundant phytochemicals of its leaf extract. Molecular docking results provided the significant prima facie evidence of the leaf extract to have antileishmanial potential. To confirm this, we performed antileishmanial and cytotoxicity assays. Methanolic extract of leaves showed growth inhibition and proliferation of promastigote with an IC value of 43.31 ± 4.202 μg/mL. It also inhibited the growth of intra-macrophagic amastigotes with an IC value of 80.76 ± 3.626 μg/mL. extract was found cytotoxic at a very high concentration on human macrophages (CC = 626 ± 39 μg/mL). Annexin V/propidium iodide (PI) staining assay suggested partial apoptosis induction in parasites by to exert its antileishmanial activity. Here, for the first time, we have shown the antileishmanial potential of leaves. Overall, our results could open new insight for an affordable and natural antileishmanial with high efficacy and less toxicity. Cassia fistula has a wide array of biologically active and therapeutically important class of compounds. Leishmania donovani important drug targets, sterol 24-c methyltransferase (LdSMT), trypanothione reductase (LdTR), pteridine reductase (LdPTR1), and nucleoside hydrolase (LdNH), were modelled, and molecular docking was performed against the abundant phytochemicals of its leaf extract. Molecular docking results provided the significant prima facie evidence of the leaf extract to have antileishmanial potential. To confirm this, we performed in vitro antileishmanial and cytotoxicity assays. Methanolic extract of C. fistula leaves showed growth inhibition and proliferation of L. donovani promastigote with an IC50 value of 43.31 ± 4.202 μg/mL. It also inhibited the growth of intra-macrophagic amastigotes with an IC50 value of 80.76 ± 3.626 μg/mL. C. fistula extract was found cytotoxic at a very high concentration on human macrophages (CC50 = 626 ± 39 μg/mL). Annexin V/propidium iodide (PI) staining assay suggested partial apoptosis induction in parasites by C. fistula to exert its antileishmanial activity. Here, for the first time, we have shown the antileishmanial potential of C. fistula leaves. Overall, our results could open new insight for an affordable and natural antileishmanial with high efficacy and less toxicity. |
| Author | Alouffi, Abdulaziz S Tabrez, Shams Rub, Abdur Ali, Rahat Alshehri, Bader Mohammed Alshammari, Fahdah Ayed Bin Dukhyil, Abdul Aziz Alaidarous, Mohammed A Rahman, Fazlur Banawas, Saeed |
| AuthorAffiliation | Infection and Immunity Lab , Department of Biotechnology Health and Basic Sciences Research Center Department of Biomedical Sciences Majmaah University Oregon State University College of Sciences and Literature Microbiology Department of Medical Laboratory Sciences, College of Applied Medical Sciences |
| AuthorAffiliation_xml | – name: Infection and Immunity Lab , Department of Biotechnology – name: Department of Biomedical Sciences – name: Oregon State University – name: Health and Basic Sciences Research Center – name: Department of Medical Laboratory Sciences, College of Applied Medical Sciences – name: Majmaah University – name: College of Sciences and Literature Microbiology |
| Author_xml | – sequence: 1 givenname: Shams surname: Tabrez fullname: Tabrez, Shams organization: Infection and Immunity Lab , Department of Biotechnology – sequence: 2 givenname: Fazlur surname: Rahman fullname: Rahman, Fazlur organization: Infection and Immunity Lab , Department of Biotechnology – sequence: 3 givenname: Rahat surname: Ali fullname: Ali, Rahat organization: Infection and Immunity Lab , Department of Biotechnology – sequence: 4 givenname: Abdulaziz S surname: Alouffi fullname: Alouffi, Abdulaziz S – sequence: 5 givenname: Bader Mohammed surname: Alshehri fullname: Alshehri, Bader Mohammed organization: Department of Medical Laboratory Sciences, College of Applied Medical Sciences – sequence: 6 givenname: Fahdah Ayed surname: Alshammari fullname: Alshammari, Fahdah Ayed organization: College of Sciences and Literature Microbiology – sequence: 7 givenname: Mohammed A surname: Alaidarous fullname: Alaidarous, Mohammed A organization: Majmaah University – sequence: 8 givenname: Saeed surname: Banawas fullname: Banawas, Saeed organization: Oregon State University – sequence: 9 givenname: Abdul Aziz surname: Bin Dukhyil fullname: Bin Dukhyil, Abdul Aziz organization: Majmaah University – sequence: 10 givenname: Abdur orcidid: 0000-0003-1301-0761 surname: Rub fullname: Rub, Abdur email: arub@jmi.ac.in organization: Infection and Immunity Lab , Department of Biotechnology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33521470$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_biopha_2021_112156 crossref_primary_10_1007_s11756_024_01656_y crossref_primary_10_1002_jcb_29944 crossref_primary_10_1016_j_biopha_2021_112240 crossref_primary_10_1590_s2175_97902022e21306 crossref_primary_10_1002_ddr_21820 crossref_primary_10_3389_fphar_2022_953352 crossref_primary_10_1016_j_heliyon_2022_e10251 |
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| Snippet | Cassia fistula has a wide array of biologically active and therapeutically important class of compounds. Leishmania donovani important drug targets, sterol... has a wide array of biologically active and therapeutically important class of compounds. important drug targets, sterol 24-c methyltransferase ( SMT),... Cassia fistula has a wide array of biologically active and therapeutically important class of compounds. Leishmania donovani important drug targets, sterol... |
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| Title | Assessment of the Antileishmanial Potential of Cassia fistula Leaf Extract |
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