Delayed gametocyte clearance in Plasmodium vivax malaria is associated with polymorphisms in the cytochrome P450 reductase (CPR)

• Published in: Antimicrobial agents and chemotherapy Vol. 68; no. 4; p. e0120423
• Main Authors: Salazar, Yanka Evellyn Alves Rodrigues, Louzada, Jaime, Puça, Maria Carolina Silva de Barros, Guimarães, Luiz Felipe Ferreira, Vieira, José Luiz Fernandes, Siqueira, André Machado de, Gil, José Pedro, Brito, Cristiana Ferreira Alves de, Sousa, Tais Nobrega de
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 03.04.2024
• Subjects: Antimalarials - pharmacology; Antimalarials - therapeutic use; Antimicrobial Chemotherapy; Artemisinins - pharmacology; Chloroquine - pharmacology; Cytochrome P-450 CYP2D6 - genetics; Epidemiology and Surveillance; Humans; Malaria - drug therapy; Malaria, Falciparum - drug therapy; Malaria, Vivax - drug therapy; NADPH-Ferrihemoprotein Reductase; Plasmodium falciparum; Plasmodium vivax - genetics; Primaquine - pharmacology; Primaquine - therapeutic use; Plasmodium vivax; primaquine; cytochrome P450 reductase; CYP2D6; gametocytes; malaria; pharmacogenetics
• ISSN: 0066-4804; 1098-6596; 1098-6596
• DOI: 10.1128/aac.01204-23

Primaquine (PQ) is the main drug used to eliminate dormant liver stages and prevent relapses in malaria. It also has an effect on the gametocytes of ; however, it is unclear to what extent PQ affects gametocytes. PQ metabolism involves multiple enzymes, including the highly polymorphic CYP2D6 and th...