Comparison of Isothiocyanate Metabolite Levels and Histone Deacetylase Activity in Human Subjects Consuming Broccoli Sprouts or Broccoli Supplement

• Published in: Journal of agricultural and food chemistry Vol. 59; no. 20; pp. 10955 - 10963
• Main Authors: Clarke, John D, Riedl, Ken, Bella, Deborah, Schwartz, Steven J, Stevens, Jan F, Ho, Emily
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 26.10.2011
• Subjects: Adult; analogs & derivatives; Bioactive Constituents; bioactive properties; Biological and medical sciences; blood; Brassica; broccoli; Diet; Dietary Supplements; excretion; Female; Food industries; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; Glucose; Glucose - analogs & derivatives; Glucose - metabolism; glucosinolates; Glucosinolates - metabolism; histone deacetylase; Histone Deacetylases; Histone Deacetylases - blood; Humans; Imidoesters; Imidoesters - metabolism; isothiocyanates; Isothiocyanates - metabolism; Isothiocyanates - urine; liquid chromatography; Male; mass spectrometry; metabolism; metabolites; Middle Aged; mononuclear leukocytes; neoplasms; Oximes; Plant Shoots; risk; Sulfides; Sulfides - urine; Sulfoxides; Thiocyanates; Thiocyanates - urine; thioglucosidase; urine; broccoli sprouts; isothiocyanate; sulforphane; histone deacetylase; erucin; supplement; Human; Broccoli; Vegetables; Metabolite; Histone; Isothiocyanates

Increased consumption of cruciferous vegetables such as broccoli may reduce the risk of various cancers. Myrosinase is required to convert dietary glucosinolates from broccoli into bioactive isothiocyanates. We evaluated isothiocyanate excretion profiles in healthy subjects who consumed broccoli spr...