Deficits in conditioned fear extinction in obsessive-compulsive disorder and neurobiological changes in the fear circuit

• Published in: JAMA psychiatry (Chicago, Ill.) Vol. 70; no. 6; p. 608
• Main Authors: Milad, Mohammed R, Furtak, Sharon C, Greenberg, Jennifer L, Keshaviah, Aparna, Im, Jooyeon J, Falkenstein, Martha J, Jenike, Michael, Rauch, Scott L, Wilhelm, Sabine
• Format: Journal Article
• Language: English
• Published: United States 01.06.2013
• Subjects: Adult; Brain - physiopathology; Case-Control Studies; Cross-Sectional Studies; Extinction, Psychological - physiology; Fear - physiology; Female; Functional Neuroimaging; Galvanic Skin Response - physiology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Obsessive-Compulsive Disorder - physiopathology; Young Adult

Obsessive-compulsive disorder (OCD) may be characterized by impaired self-regulation and behavioral inhibition. Elevated fear and anxiety are common characteristics of this disorder. The neurobiology of fear regulation and consolidation of safety memories have not been examined in this patient popul...