Roles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection

• Published in: Journal of virology Vol. 96; no. 3; p. e0162421
• Main Authors: Tran, Pham-Tue-Hung, Chiramel, Abhilash I., Johansson, Magnus, Melik, Wessam
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 09.02.2022
• Subjects: ALIX; Animals; assembly; Calcium-Binding Proteins - metabolism; Cell Cycle Proteins - metabolism; Cell Line; Cells, Cultured; CHMP4A; Cytokines - metabolism; Endosomal Sorting Complexes Required for Transport - metabolism; envelope; ESCRT; Flavivirus - physiology; Flavivirus Infections - metabolism; Flavivirus Infections - transmission; Flavivirus Infections - virology; HERC5; Host-Pathogen Interactions; Humans; ISG15; Models, Biological; NS3; Proteolysis; replication; replicons; tick-borne flaviviruses; Ticks - virology; TSG101; Ubiquitins - metabolism; Virology; virus late domain; Virus Replication; Virus-Cell Interactions; replication; replicons; TSG101; ALIX; ESCRT; tick-borne flaviviruses; ISG15; NS3; HERC5; envelope; assembly; CHMP4A; virus late domain
• ISSN: 0022-538X; 1098-5514; 1098-5514
• DOI: 10.1128/JVI.01624-21

Flaviviruses are important zoonotic viruses with high fatality rates worldwide. Here, we report that during infection the virus employs ESCRT protein members for virus replication and assembly. Flaviviruses are usually transmitted to humans via mosquito or tick bites. During infection, virus replica...