Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

• Published in: Archives of neurology (Chicago) Vol. 76; no. 2; p. 152
• Main Authors: Hithersay, Rosalyn, Startin, Carla M, Hamburg, Sarah, Mok, Kin Y, Hardy, John, Fisher, Elizabeth M C, Tybulewicz, Victor L J, Nizetic, Dean, Strydom, André
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 01.02.2019
• Subjects: Adult; Adults; Age; Age of Onset; Alzheimer's disease; Apolipoprotein E; Apolipoprotein E4 - genetics; Comorbidity; Consortia; Correlation analysis; Data collection; Death; Dementia; Dementia - epidemiology; Dementia - mortality; Dementia disorders; Diagnosis; Down syndrome; Down Syndrome - epidemiology; Down Syndrome - mortality; Down's syndrome; England - epidemiology; Epilepsy; Epilepsy - epidemiology; Epilepsy - mortality; Fatalities; Female; Genotypes; Hazards; Health; Health care; Heterozygote; Humans; Longitudinal Studies; Male; Middle Aged; Mortality; Neurodegenerative diseases; Older people; Survival Analysis; England

This work quantifies the fatal burden of dementia associated with Alzheimer disease in individuals with Down syndrome (DS). To explore the association of dementia associated with Alzheimer disease with mortality and examine factors associated with dementia in adults with DS. Prospective longitudinal...