Recombinant chimeric horsepox virus (TNX-801) is attenuated relative to vaccinia virus strains in both in vitro and in vivo models - Trefry, Stephanie V.; Awasthi, Mayanka; Raney, Christy N.; Cregger, Amy L.; Gonzales, Chase A.; Layton, Brittney L.; Enamorado, Robert N.; Martinez, Nelson A.; Gohegan, Deborah S.; Masoud-Bahnamiri, Masoudeh; Cho, Jennifer Y.; Myscofski, Dawn M.; et al. (mSphere, 2024)
Keywords: Animals; Biotechnology; Cell Line; Chlorocebus aethiops; Disease Models, Animal; Editor’s Pick; Female; Fowlpox virus - genetics; Fowlpox virus - immunology; horsepox; human primary cells; Humans; immunocompromised mice; Mice; Orthopoxvirus; Research Article; Smallpox - immunology; Smallpox - prevention & control; Smallpox Vaccine - genetics; Smallpox Vaccine - immunology; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; vaccinia; Vaccinia virus - genetics; Vaccinia virus - immunology; Vero Cells; Virus Replication - drug effects; immunocompromised mice; human primary cells; vaccinia; Orthopoxvirus; horsepox