The Interplay of Size and Surface Functionality on the Cellular Uptake of Sub-10 nm Gold Nanoparticles

• Published in: ACS nano Vol. 9; no. 10; pp. 9986 - 9993
• Main Authors: Jiang, Ying, Huo, Shuaidong, Mizuhara, Tsukasa, Das, Riddha, Lee, Yi-Wei, Hou, Singyuk, Moyano, Daniel F, Duncan, Bradley, Liang, Xing-Jie, Rotello, Vincent M
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.10.2015
• Subjects: Anions - chemistry; Anions - metabolism; Cations - chemistry; Cations - metabolism; Diffusion; Endocytosis; Gold - chemistry; Gold - metabolism; HeLa Cells; Humans; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; Particle Size; Static Electricity; Surface Properties; passive fusion; surface charge; endocytosis pathway; sub-10 nm gold nanoparticles; size-dependent

Correlation of the surface physicochemical properties of nanoparticles with their interactions with biosystems provides key foundational data for nanomedicine. We report here the systematic synthesis of 2, 4, and 6 nm core gold nanoparticles (AuNP) featuring neutral (zwitterionic), anionic, and cati...