Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV‑2 Papain-Like Protease - Freitas, Brendan T; Durie, Ian A; Murray, Jackelyn; Longo, Jaron E; Miller, Holden C; Crich, David; Hogan, Robert Jeff; Tripp, Ralph A; Pegan, Scott D (ACS infectious diseases, 2020)
Keywords: Amino Acid Sequence; Animals; Betacoronavirus - enzymology; Binding Sites; Chlorocebus aethiops; Coronavirus 3C Proteases; Coronavirus Infections - virology; COVID-19; Cysteine Endopeptidases - chemistry; Cysteine Endopeptidases - metabolism; Cytokines - antagonists & inhibitors; Cytokines - chemistry; Cytokines - metabolism; Deubiquitinating Enzymes - antagonists & inhibitors; Humans; Naphthalenes - pharmacology; Pandemics; Pneumonia, Viral - virology; Protein Binding; Protein Conformation; SARS-CoV-2; Substrate Specificity; Ubiquitin - metabolism; Ubiquitins - antagonists & inhibitors; Ubiquitins - chemistry; Ubiquitins - metabolism; Vero Cells; Viral Nonstructural Proteins - antagonists & inhibitors; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - metabolism; Virus Replication - drug effects; COVID-19; severe acute respiratory syndrome 2; coronavirus; PLpro; ISG5; ubiquitin