Mining the Biosynthetic Landscape of Lactic Acid Bacteria Unearths a New Family of RiPPs Assembled by a Novel Type of ThiF-like Adenylyltransferases

• Published in: ACS omega Vol. 9; no. 28; pp. 30891 - 30903
• Main Authors: Wang, Mengjiao, Wu, Mengyue, Han, Meng, Niu, Xiaogang, Fan, Aili, Zhu, Shaozhou, Tong, Yigang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 16.07.2024

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are chemically diverse natural products of ribosomal origin. These peptides, which frequently act as signals or antimicrobials, are biosynthesized by conserved enzymatic machinery, making genome mining a powerful strategy for...