In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients

• Published in: Journal of proteome research Vol. 18; no. 6; pp. 2601 - 2612
• Main Authors: Wu, Xia, Siehnel, Richard J, Garudathri, Jayanthi, Staudinger, Benjamin J, Hisert, Katherine B, Ozer, Egon A, Hauser, Alan R, Eng, Jimmy K, Manoil, Colin, Singh, Pradeep K, Bruce, James E
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.06.2019
• Subjects: Adult; Anti-Bacterial Agents - therapeutic use; Bacterial Proteins - genetics; Carbon - metabolism; Cystic Fibrosis - diagnosis; Cystic Fibrosis - drug therapy; Cystic Fibrosis - genetics; Cystic Fibrosis - microbiology; Female; Glyoxylates - metabolism; Humans; Lactic Acid - metabolism; Male; Membrane Proteins - genetics; Middle Aged; Proteome - genetics; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - isolation & purification; Pseudomonas aeruginosa - pathogenicity; Pseudomonas Infections - diagnosis; Pseudomonas Infections - drug therapy; Pseudomonas Infections - genetics; Pseudomonas Infections - microbiology; Sputum - microbiology; Pseudomonas aeruginosa; cystic fibrosis; quantitative proteomics; bacterial population proteomes

Chronic airway infection with P. aeruginosa (PA) is a hallmark of cystic fibrosis (CF) disease. The mechanisms producing PA persistence in CF therapies remain poorly understood. To gain insight on PA physiology in patient airways and better understand how in vivo bacterial functioning differs from i...