Core–Shell Plasmonic Nanomaterials toward: Dual-Mode Imaging Analysis of Glutathione and Enhanced Chemodynamic Therapy

A simple process, rich information, and intelligent response are the goals pursued by cancer diagnosis and treatment. Herein, we developed a core–shell plasmonic nanomaterial (Au@MnO2-DNA), which consisted of a AuNP core with an outer shell MnO2 nanosheet decorated with fluorophore modified DNA, to...

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Published inAnalytical chemistry (Washington) Vol. 93; no. 29; pp. 10317 - 10325
Main Authors Wang, Jin, Liu, Ying-Xue, Li, Xiang-Ling, Chen, Hong-Yuan, Xu, Jing-Juan
Format Journal Article
LanguageEnglish
Published Washington American Chemical Society 27.07.2021
Subjects
adverse effects
Analytical chemistry
Cancer
cancer therapy
Chemistry
Deoxyribonucleic acid
DNA
DNA probes
Fluorescence
fluorescent dyes
Glutathione
Information processing
Intracellular
light microscopes
Manganese dioxide
Medical imaging
Nanomaterials
Nanoparticles
nanosheets
Nanotechnology
Optical microscopes
Optical properties
Plasmonics
Switching
Therapy
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Abstract A simple process, rich information, and intelligent response are the goals pursued by cancer diagnosis and treatment. Herein, we developed a core–shell plasmonic nanomaterial (Au@MnO2-DNA), which consisted of a AuNP core with an outer shell MnO2 nanosheet decorated with fluorophore modified DNA, to achieve the aforementioned aims. On the basis of the unique optical properties of plasmonic nanoparticles and the oxidability of the shell MnO2, scattering signal and fluorescence (FL) signal changes were both related to the expression level of glutathione (GSH), for which a dual-mode imaging analysis was successfully achieved on single optical microscope equipment with one-key switching. Meanwhile, the product of Mn2+ from the reaction between MnO2 and GSH not only served as a smart chemodynamic agent to initiate Fenton-like reaction for achieving chemodynamic therapy (CDT) of cancer cells but also relieved the side effect of intracellular GSH in cancer therapy. Therefore, the core–shell plasmonic nanomaterials with dual modal switching features and diagnostic properties act as excellent probes for achieving bioanalysis of aberrant levels of intracellular GSH and simultaneously activating the CDT of cancer cells based on the in situ reactions in cancer cells.
AbstractList A simple process, rich information, and intelligent response are the goals pursued by cancer diagnosis and treatment. Herein, we developed a core–shell plasmonic nanomaterial (Au@MnO₂-DNA), which consisted of a AuNP core with an outer shell MnO₂ nanosheet decorated with fluorophore modified DNA, to achieve the aforementioned aims. On the basis of the unique optical properties of plasmonic nanoparticles and the oxidability of the shell MnO₂, scattering signal and fluorescence (FL) signal changes were both related to the expression level of glutathione (GSH), for which a dual-mode imaging analysis was successfully achieved on single optical microscope equipment with one-key switching. Meanwhile, the product of Mn²⁺ from the reaction between MnO₂ and GSH not only served as a smart chemodynamic agent to initiate Fenton-like reaction for achieving chemodynamic therapy (CDT) of cancer cells but also relieved the side effect of intracellular GSH in cancer therapy. Therefore, the core–shell plasmonic nanomaterials with dual modal switching features and diagnostic properties act as excellent probes for achieving bioanalysis of aberrant levels of intracellular GSH and simultaneously activating the CDT of cancer cells based on the in situ reactions in cancer cells.
A simple process, rich information, and intelligent response are the goals pursued by cancer diagnosis and treatment. Herein, we developed a core–shell plasmonic nanomaterial (Au@MnO2-DNA), which consisted of a AuNP core with an outer shell MnO2 nanosheet decorated with fluorophore modified DNA, to achieve the aforementioned aims. On the basis of the unique optical properties of plasmonic nanoparticles and the oxidability of the shell MnO2, scattering signal and fluorescence (FL) signal changes were both related to the expression level of glutathione (GSH), for which a dual-mode imaging analysis was successfully achieved on single optical microscope equipment with one-key switching. Meanwhile, the product of Mn2+ from the reaction between MnO2 and GSH not only served as a smart chemodynamic agent to initiate Fenton-like reaction for achieving chemodynamic therapy (CDT) of cancer cells but also relieved the side effect of intracellular GSH in cancer therapy. Therefore, the core–shell plasmonic nanomaterials with dual modal switching features and diagnostic properties act as excellent probes for achieving bioanalysis of aberrant levels of intracellular GSH and simultaneously activating the CDT of cancer cells based on the in situ reactions in cancer cells.
A simple process, rich information, and intelligent response are the goals pursued by cancer diagnosis and treatment. Herein, we developed a core-shell plasmonic nanomaterial (Au@MnO2-DNA), which consisted of a AuNP core with an outer shell MnO2 nanosheet decorated with fluorophore modified DNA, to achieve the aforementioned aims. On the basis of the unique optical properties of plasmonic nanoparticles and the oxidability of the shell MnO2, scattering signal and fluorescence (FL) signal changes were both related to the expression level of glutathione (GSH), for which a dual-mode imaging analysis was successfully achieved on single optical microscope equipment with one-key switching. Meanwhile, the product of Mn2+ from the reaction between MnO2 and GSH not only served as a smart chemodynamic agent to initiate Fenton-like reaction for achieving chemodynamic therapy (CDT) of cancer cells but also relieved the side effect of intracellular GSH in cancer therapy. Therefore, the core-shell plasmonic nanomaterials with dual modal switching features and diagnostic properties act as excellent probes for achieving bioanalysis of aberrant levels of intracellular GSH and simultaneously activating the CDT of cancer cells based on the in situ reactions in cancer cells.A simple process, rich information, and intelligent response are the goals pursued by cancer diagnosis and treatment. Herein, we developed a core-shell plasmonic nanomaterial (Au@MnO2-DNA), which consisted of a AuNP core with an outer shell MnO2 nanosheet decorated with fluorophore modified DNA, to achieve the aforementioned aims. On the basis of the unique optical properties of plasmonic nanoparticles and the oxidability of the shell MnO2, scattering signal and fluorescence (FL) signal changes were both related to the expression level of glutathione (GSH), for which a dual-mode imaging analysis was successfully achieved on single optical microscope equipment with one-key switching. Meanwhile, the product of Mn2+ from the reaction between MnO2 and GSH not only served as a smart chemodynamic agent to initiate Fenton-like reaction for achieving chemodynamic therapy (CDT) of cancer cells but also relieved the side effect of intracellular GSH in cancer therapy. Therefore, the core-shell plasmonic nanomaterials with dual modal switching features and diagnostic properties act as excellent probes for achieving bioanalysis of aberrant levels of intracellular GSH and simultaneously activating the CDT of cancer cells based on the in situ reactions in cancer cells.
Author Wang, Jin
Liu, Ying-Xue
Chen, Hong-Yuan
Xu, Jing-Juan
Li, Xiang-Ling
AuthorAffiliation State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering
Nanjing Tech University
College of Life Science and Pharmaceutical Engineering
AuthorAffiliation_xml – name: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering
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  givenname: Jin
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  surname: Liu
  fullname: Liu, Ying-Xue
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  surname: Li
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  organization: Nanjing Tech University
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  givenname: Hong-Yuan
  surname: Chen
  fullname: Chen, Hong-Yuan
  organization: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering
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  givenname: Jing-Juan
  orcidid: 0000-0001-9579-9318
  surname: Xu
  fullname: Xu, Jing-Juan
  email: xujj@nju.edu.cn
  organization: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering
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Snippet A simple process, rich information, and intelligent response are the goals pursued by cancer diagnosis and treatment. Herein, we developed a core–shell...
A simple process, rich information, and intelligent response are the goals pursued by cancer diagnosis and treatment. Herein, we developed a core-shell...
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SubjectTerms adverse effects
Analytical chemistry
Cancer
cancer therapy
Chemistry
Deoxyribonucleic acid
DNA
DNA probes
Fluorescence
fluorescent dyes
Glutathione
Information processing
Intracellular
light microscopes
Manganese dioxide
Medical imaging
Nanomaterials
Nanoparticles
nanosheets
Nanotechnology
Optical microscopes
Optical properties
Plasmonics
Switching
Therapy
Title Core–Shell Plasmonic Nanomaterials toward: Dual-Mode Imaging Analysis of Glutathione and Enhanced Chemodynamic Therapy
URI http://dx.doi.org/10.1021/acs.analchem.1c01858
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