Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria

• Published in: ACS chemical biology Vol. 18; no. 2; pp. 367 - 376
• Main Authors: Tanoeyadi, Samuel, Tsunoda, Takeshi, Ito, Takuya, Philmus, Benjamin, Mahmud, Taifo
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.02.2023
• Subjects: Acarbose; Actinobacteria - metabolism; alpha-Amylases - metabolism; Bacterial Proteins - metabolism; Diabetes Mellitus, Type 2; Humans

Acarbose is a well-known microbial specialized metabolite used clinically to treat type 2 diabetes. This natural pseudo-oligosaccharide (PsOS) shows potent inhibitory activity toward various glycosyl hydrolases, including α-glucosidases and α-amylases. While acarbose and other PsOSs are produced by...